Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.1751 | 0.3476 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.1751 | 0.3476 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.1751 | 0.3476 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.1751 | 0.3476 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0613 | 0.086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0819 | 0.1334 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.4589 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0408 | 0.0388 | 0.0757 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.4589 | 1 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.4589 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.4589 | 1 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.4589 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.1751 | 0.3476 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0374 | 0.031 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.4589 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0408 | 0.0388 | 1 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.039 | 0.0347 | 1 |
Toxoplasma gondii | hypothetical protein | 0.4589 | 1 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0613 | 0.086 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.4589 | 1 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0374 | 0.031 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.1751 | 0.3476 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.039 | 0.0347 | 0.3943 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.1751 | 0.3476 | 0.5 |
Echinococcus granulosus | adam 17 protease | 0.0429 | 0.0436 | 0.4998 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Antiproliferative activity in vitro against HT-29 (human colon carcinoma) cell line. | ChEMBL. | 11882002 |
IC50 (functional) | > 10 uM | Antiproliferative activity in vitro against A549 (human non-small lung carcinoma) cell line. | ChEMBL. | 11882002 |
IC50 (functional) | > 10 uM | Antiproliferative activity in vitro against K-562 (human leukemia) cell line. | ChEMBL. | 11882002 |
IC50 (functional) | > 10 uM | Antiproliferative activity in vitro against HT-29 (human colon carcinoma) cell line. | ChEMBL. | 11882002 |
IC50 (functional) | > 10 uM | Antiproliferative activity in vitro against A549 (human non-small lung carcinoma) cell line. | ChEMBL. | 11882002 |
IC50 (functional) | > 10 uM | Antiproliferative activity in vitro against K-562 (human leukemia) cell line. | ChEMBL. | 11882002 |
IC50 (functional) | = 70.3 uM | Antiproliferative activity tested in vitro against L1210 (murine leukemia) cell line. | ChEMBL. | 11882002 |
IC50 (functional) | = 70.3 uM | Antiproliferative activity tested in vitro against L1210 (murine leukemia) cell line. | ChEMBL. | 11882002 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11882002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.