Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Squalene phytoene synthase | 0.0526 | 0.2617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0704 | 0.3748 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0526 | 0.2617 | 0.6981 |
Trypanosoma cruzi | squalene synthase, putative | 0.1687 | 1 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.023 | 0.0738 | 0.2105 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0511 | 0.2522 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0511 | 0.2522 | 0.9603 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0526 | 0.2617 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0511 | 0.2522 | 0.9603 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0511 | 0.2522 | 0.9603 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0187 | 0.0465 | 0.0955 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0526 | 0.2617 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.0321 | 0.1315 | 0.453 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.0543 | 0.1448 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0526 | 0.2617 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0285 | 0.1088 | 0.3574 |
Echinococcus granulosus | adam 17 protease | 0.0365 | 0.1594 | 0.5702 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0511 | 0.2522 | 0.9603 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0152 | 0.0237 | 0.07 |
Trypanosoma cruzi | squalene synthase, putative | 0.1687 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.02 | 0.0543 | 0.1283 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0321 | 0.1315 | 0.453 |
Echinococcus multilocularis | serotonin receptor | 0.02 | 0.0543 | 0.1283 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0187 | 0.0465 | 0.0955 |
Trypanosoma brucei | squalene synthase, putative | 0.1687 | 1 | 0.5 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.023 | 0.0738 | 0.2105 |
Loa Loa (eye worm) | matrixin family protein | 0.0125 | 0.0066 | 0.0175 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0511 | 0.2522 | 0.9603 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0511 | 0.2522 | 0.6729 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0285 | 0.1088 | 0.3574 |
Schistosoma mansoni | hypothetical protein | 0.0526 | 0.2617 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0511 | 0.2522 | 0.9603 |
Echinococcus multilocularis | neuropeptide receptor | 0.0285 | 0.1088 | 0.3574 |
Schistosoma mansoni | neuropeptide receptor | 0.0285 | 0.1088 | 0.3574 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0526 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.2522 | 0.6729 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.0543 | 0.1448 |
Echinococcus multilocularis | serotonin receptor | 0.02 | 0.0543 | 0.1283 |
Onchocerca volvulus | Putative nachr subunit | 0.0511 | 0.2522 | 0.9639 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.02 | 0.0543 | 0.1283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration against Plasmodium falciparum NF-54 strain upon incubation for 40 h | ChEMBL. | 16168643 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration against Plasmodium falciparum NF-54 strain upon incubation for 40 h | ChEMBL. | 16168643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.