Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0227 | 0.0558 | 0.2024 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0241 | 0.0757 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0241 | 0.0757 | 0.0498 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0261 | 0.1043 | 0.0309 |
Leishmania major | ribonuclease H1, putative | 0.0241 | 0.0757 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0241 | 0.0757 | 0.0498 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0227 | 0.0558 | 0.2024 |
Giardia lamblia | Ribonuclease H | 0.0241 | 0.0757 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0227 | 0.0558 | 0.2024 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0241 | 0.0757 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0206 | 0.0272 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0227 | 0.0558 | 0.2024 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0227 | 0.0558 | 0.2024 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0261 | 0.1043 | 0.0309 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0241 | 0.0757 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0227 | 0.0558 | 0.2024 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0311 | 0.1742 | 0.1511 |
Brugia malayi | RNase H family protein | 0.0241 | 0.0757 | 1 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0241 | 0.0757 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0241 | 0.0757 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0227 | 0.0558 | 0.2024 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0227 | 0.0558 | 0.2024 |
Trypanosoma brucei | RNA helicase, putative | 0.0903 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0206 | 0.0272 | 0.0988 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0206 | 0.0272 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0384 | 0.2758 | 1 |
Toxoplasma gondii | ribonuclease HI protein | 0.0241 | 0.0757 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0227 | 0.0558 | 0.2024 |
Schistosoma mansoni | phosphoglucomutase | 0.0241 | 0.0757 | 0.0498 |
Brugia malayi | RNase H family protein | 0.0241 | 0.0757 | 1 |
Brugia malayi | RNase H family protein | 0.0241 | 0.0757 | 1 |
Trypanosoma brucei | unspecified product | 0.0261 | 0.1043 | 0.0309 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0384 | 0.2758 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0261 | 0.1043 | 0.0309 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0384 | 0.2758 | 0.2555 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0241 | 0.0757 | 0.5 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0261 | 0.1043 | 0.0309 |
Echinococcus multilocularis | ribonuclease H1 | 0.0241 | 0.0757 | 0.2745 |
Echinococcus granulosus | ribonuclease H1 | 0.0241 | 0.0757 | 0.2745 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0227 | 0.0558 | 0.2024 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50 uM | Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer) | ChEMBL. | 16190757 |
IC50 (binding) | = 50 uM | Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer) | ChEMBL. | 16190757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.