Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase I | 0.0054 | 0.1241 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0175 | 0.5468 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.0222 | 0.7088 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.011 | 0.3167 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0175 | 0.5468 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0083 | 0.225 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0054 | 0.1241 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0083 | 0.225 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0083 | 0.225 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0054 | 0.1241 | 0.5 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0175 | 0.5468 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0083 | 0.225 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0175 | 0.5468 | 0.5 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0175 | 0.5468 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0175 | 0.5468 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.011 | 0.3167 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.225 | 1 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0175 | 0.5468 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0083 | 0.225 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.011 | 0.3167 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.0175 | 0.5468 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0083 | 0.225 | 1 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.011 | 0.3167 | 1 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0175 | 0.5468 | 0.744 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0054 | 0.1241 | 0.5 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0054 | 0.1241 | 1 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0175 | 0.5468 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.225 | 1 |
Treponema pallidum | DNA polymerase I (polA) | 0.0054 | 0.1241 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3700 nM | Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes | ChEMBL. | 16134949 |
IC50 (binding) | = 3700 nM | Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes | ChEMBL. | 16134949 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.