Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0417 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0417 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0417 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0417 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0417 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0417 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0417 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0417 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0417 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0417 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0417 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0417 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0417 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0417 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0417 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 1000 nM | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16366607 |
Ki (binding) | > 1000 nM | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16366607 |
Ki (binding) | > 10000 nM | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 16366607 |
Ki (binding) | > 10000 nM | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 16366607 |
Ki (binding) | > 10000 nM | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 16366607 |
Ki (binding) | > 10000 nM | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 16366607 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.