Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0149 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0149 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0149 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0149 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0149 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0149 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0149 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0149 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0149 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0149 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 % | In vitro effect on the G1 phase of cell cycle of U2OS cells upon incubation at 37 degree for 24 hours in FCM assay; all the cell died at tested concentration (500 nM) | ChEMBL. | 16137880 |
Activity (functional) | 0 % | In vitro effect on the S phase of cell cycle of U2OS cells upon incubation at 37 degree for 24 hours in FCM assay; all the cell died at tested concentration (500 nM) | ChEMBL. | 16137880 |
Activity (functional) | 0 % | In vitro effect on the G2/M phase of cell cycle of U2OS cells upon incubation at 37 degree for 24 hours in FCM assay; all the cell died at tested concentration (500 nM) | ChEMBL. | 16137880 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.