Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | histone deacetylase, putative | 0.0668 | 0.1486 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0631 | 0.1399 | 0.9404 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0275 | 0.0562 | 0.3781 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0668 | 0.1486 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0275 | 0.0562 | 0.365 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0275 | 0.0562 | 0.365 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0631 | 0.1399 | 0.9417 |
Schistosoma mansoni | histone deacetylase | 0.0668 | 0.1486 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0668 | 0.1486 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0275 | 0.0562 | 0.3781 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0668 | 0.1486 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0631 | 0.1399 | 0.9404 |
Brugia malayi | Histone deacetylase 1 | 0.0668 | 0.1486 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0668 | 0.1486 | 1 |
Trichomonas vaginalis | UDP-glucose 4-epimerase, putative | 0.0054 | 0.0045 | 0.0098 |
Echinococcus multilocularis | histone deacetylase | 0.0631 | 0.1399 | 0.9417 |
Leishmania major | histone deacetylase, putative | 0.0668 | 0.1486 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.065 | 0.1443 | 0.9714 |
Trypanosoma brucei | histone deacetylase, putative | 0.0631 | 0.1399 | 0.9404 |
Brugia malayi | Uncharacterized LmbE-like protein, COG2120 containing protein | 0.0048 | 0.0031 | 0.0206 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0041 | 0.0012 | 0.0083 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0275 | 0.0562 | 0.365 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0275 | 0.0562 | 0.365 |
Echinococcus granulosus | N acetylglucosaminyl phosphatidylinositol | 0.0048 | 0.0031 | 0.0206 |
Trypanosoma brucei | histone deacetylase 1 | 0.0668 | 0.1486 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0668 | 0.1486 | 1 |
Echinococcus multilocularis | N acetylglucosaminyl phosphatidylinositol | 0.0048 | 0.0031 | 0.0206 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0668 | 0.1486 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0668 | 0.1486 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0668 | 0.1486 | 1 |
Brugia malayi | UDP galactose 4'-epimerase | 0.0054 | 0.0045 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0668 | 0.1486 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0089 | 0.0126 | 0.0657 |
Mycobacterium tuberculosis | Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) | 0.4248 | 0.9887 | 1 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0054 | 0.0045 | 0.0098 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0631 | 0.1399 | 0.9404 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0631 | 0.1399 | 0.9417 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0631 | 0.1399 | 0.9404 |
Brugia malayi | histone deacetylase 11 | 0.0275 | 0.0562 | 0.3781 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0668 | 0.1486 | 1 |
Loa Loa (eye worm) | phosphatidylinositol glycan anchor biosynthesis protein | 0.0048 | 0.0031 | 0.0206 |
Mycobacterium ulcerans | mycothiol conjugate amidase Mca | 0.4296 | 1 | 1 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.0054 | 0.0045 | 0.0302 |
Schistosoma mansoni | histone deacetylase | 0.0668 | 0.1486 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0631 | 0.1399 | 0.9417 |
Plasmodium vivax | histone deacetylase, putative | 0.0275 | 0.0562 | 0.365 |
Plasmodium falciparum | histone deacetylase, putative | 0.0631 | 0.1399 | 0.9404 |
Onchocerca volvulus | 0.0041 | 0.0012 | 0.0221 | |
Entamoeba histolytica | UDP-glucose 4-epimerase, putative | 0.0054 | 0.0045 | 0.0098 |
Leishmania major | histone deacetylase, putative | 0.0631 | 0.1399 | 0.9404 |
Brugia malayi | Histone deacetylase family protein | 0.0631 | 0.1399 | 0.9417 |
Echinococcus granulosus | histone deacetylase 6 | 0.0631 | 0.1399 | 0.9417 |
Echinococcus granulosus | histone deacetylase 7 | 0.0631 | 0.1399 | 0.9417 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0668 | 0.1486 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.0054 | 0.0045 | 0.0098 |
Echinococcus granulosus | histone deacetylase 1 | 0.0668 | 0.1486 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0631 | 0.1399 | 0.9417 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0668 | 0.1486 | 1 |
Leishmania major | udp-glc 4-epimerase, putative | 0.0052 | 0.004 | 0.0067 |
Giardia lamblia | Histone deacetylase | 0.0668 | 0.1486 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0275 | 0.0562 | 0.3781 |
Echinococcus granulosus | histone deacetylase | 0.0631 | 0.1399 | 0.9417 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.0562 | 0.3781 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0668 | 0.1486 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0668 | 0.1486 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0668 | 0.1486 | 1 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.0054 | 0.0045 | 0.0098 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0631 | 0.1399 | 0.9417 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0668 | 0.1486 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0668 | 0.1486 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0668 | 0.1486 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0668 | 0.1486 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.0054 | 0.0045 | 0.0098 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0631 | 0.1399 | 0.9404 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.0052 | 0.004 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.0755 | 0.5079 |
Loa Loa (eye worm) | histone deacetylase | 0.0631 | 0.1399 | 0.9417 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.0054 | 0.0045 | 0.0302 |
Entamoeba histolytica | histone deacetylase, putative | 0.0668 | 0.1486 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0631 | 0.1399 | 0.9417 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0041 | 0.0012 | 0.0083 |
Schistosoma mansoni | N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase | 0.0048 | 0.0031 | 0.0206 |
Echinococcus granulosus | histone deacetylase 6 | 0.065 | 0.1443 | 0.9714 |
Plasmodium falciparum | histone deacetylase 2 | 0.0631 | 0.1399 | 0.9404 |
Giardia lamblia | UDP-glucose 4-epimerase | 0.0052 | 0.004 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 0.0799 | 0.5376 |
Plasmodium vivax | histone deacetylase, putative | 0.0631 | 0.1399 | 0.9404 |
Echinococcus granulosus | disco interacting protein 2 | 0.0041 | 0.0012 | 0.0083 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0668 | 0.1486 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0089 | 0.0126 | 0.0657 |
Echinococcus granulosus | histone deacetylase 8 | 0.0275 | 0.0562 | 0.3781 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0668 | 0.1486 | 1 |
Leishmania major | histone deacetylase, putative | 0.0631 | 0.1399 | 0.9404 |
Trypanosoma brucei | histone deacetylase 2 | 0.0275 | 0.0562 | 0.365 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0054 | 0.0045 | 0.0098 |
Leishmania major | histone deacetylase, putative | 0.0668 | 0.1486 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0631 | 0.1399 | 0.9404 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.0054 | 0.0045 | 0.0302 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.0054 | 0.0045 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0012 | 0.0083 |
Echinococcus multilocularis | histone deacetylase 6 | 0.065 | 0.1443 | 0.9714 |
Echinococcus granulosus | histone deacetylase 6 | 0.0631 | 0.1399 | 0.9417 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0275 | 0.0562 | 0.3781 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0041 | 0.0012 | 0.0083 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0275 | 0.0562 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0631 | 0.1399 | 0.9417 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0668 | 0.1486 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0631 | 0.1399 | 0.9404 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.7 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma | ChEMBL. | 16302797 |
IC50 (binding) | = 5.1 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP | ChEMBL. | 16302797 |
IC50 (binding) | = 6.9 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione | ChEMBL. | 16302797 |
IC50 (binding) | = 11.2 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 1 mm ATP | ChEMBL. | 16302797 |
IC50 (binding) | = 189 nM | Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cells | ChEMBL. | 16302797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.