Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | histone deacetylase, putative | 0.0193 | 0.0354 | 0.3111 |
Echinococcus granulosus | histone deacetylase 8 | 0.0193 | 0.0354 | 0.3177 |
Brugia malayi | Histone deacetylase 1 | 0.048 | 0.1006 | 0.9406 |
Echinococcus granulosus | histone deacetylase 6 | 0.0508 | 0.1069 | 0.9604 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0193 | 0.0354 | 0.3177 |
Schistosoma mansoni | histone deacetylase | 0.048 | 0.1006 | 0.9034 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0508 | 0.1069 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0508 | 0.1069 | 0.9604 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0508 | 0.1069 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0508 | 0.1069 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0508 | 0.1069 | 0.9604 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0528 | 0.1113 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0193 | 0.0354 | 0.3177 |
Echinococcus multilocularis | histone deacetylase 1 | 0.048 | 0.1006 | 0.9034 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0508 | 0.1069 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.048 | 0.1006 | 1 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.0056 | 0.0045 | 0.042 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0042 | 0.0012 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0354 | 0.3308 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0193 | 0.0354 | 0.3308 |
Echinococcus granulosus | N acetylglucosaminyl phosphatidylinositol | 0.005 | 0.0031 | 0.0275 |
Leishmania major | histone deacetylase, putative | 0.0508 | 0.1069 | 1 |
Leishmania major | histone deacetylase, putative | 0.0508 | 0.1069 | 1 |
Brugia malayi | Uncharacterized LmbE-like protein, COG2120 containing protein | 0.005 | 0.0031 | 0.0286 |
Entamoeba histolytica | histone deacetylase, putative | 0.048 | 0.1006 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.048 | 0.1006 | 0.9034 |
Loa Loa (eye worm) | phosphatidylinositol glycan anchor biosynthesis protein | 0.005 | 0.0031 | 0.0286 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0092 | 0.0126 | 0.0921 |
Mycobacterium tuberculosis | Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) | 0.4398 | 0.9887 | 1 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.0056 | 0.0045 | 0.0138 |
Plasmodium falciparum | histone deacetylase 1 | 0.048 | 0.1006 | 0.9389 |
Echinococcus multilocularis | histone deacetylase 3 | 0.048 | 0.1006 | 0.9034 |
Schistosoma mansoni | histone deacetylase | 0.048 | 0.1006 | 0.9034 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0508 | 0.1069 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0508 | 0.1069 | 1 |
Trichomonas vaginalis | UDP-glucose 4-epimerase, putative | 0.0056 | 0.0045 | 0.0147 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0508 | 0.1069 | 0.9604 |
Echinococcus granulosus | histone deacetylase 1 | 0.048 | 0.1006 | 0.9034 |
Mycobacterium ulcerans | mycothiol conjugate amidase Mca | 0.4448 | 1 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0193 | 0.0354 | 0.3308 |
Echinococcus multilocularis | N acetylglucosaminyl phosphatidylinositol | 0.005 | 0.0031 | 0.0275 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0508 | 0.1069 | 0.9604 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.048 | 0.1006 | 0.9406 |
Onchocerca volvulus | 0.0042 | 0.0012 | 0.035 | |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.0056 | 0.0045 | 0.0138 |
Echinococcus granulosus | histone deacetylase 6 | 0.0508 | 0.1069 | 0.9604 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.048 | 0.1006 | 1 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0193 | 0.0354 | 0.3111 |
Trichomonas vaginalis | histone deacetylase, putative | 0.048 | 0.1006 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.048 | 0.1006 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.048 | 0.1006 | 0.9389 |
Brugia malayi | Histone deacetylase family protein | 0.0508 | 0.1069 | 1 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.0056 | 0.0045 | 0.0404 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.0056 | 0.0045 | 0.0404 |
Plasmodium vivax | histone deacetylase 1, putative | 0.048 | 0.1006 | 0.9389 |
Giardia lamblia | UDP-glucose 4-epimerase | 0.0054 | 0.004 | 0.0101 |
Trypanosoma brucei | histone deacetylase, putative | 0.0508 | 0.1069 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0508 | 0.1069 | 0.9604 |
Trichomonas vaginalis | histone deacetylase, putative | 0.048 | 0.1006 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0508 | 0.1069 | 1 |
Leishmania major | histone deacetylase, putative | 0.048 | 0.1006 | 0.9389 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0508 | 0.1069 | 0.9604 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0508 | 0.1069 | 0.9604 |
Trypanosoma brucei | histone deacetylase 2 | 0.0193 | 0.0354 | 0.3111 |
Plasmodium falciparum | histone deacetylase 2 | 0.0508 | 0.1069 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0193 | 0.0354 | 0.3177 |
Echinococcus granulosus | histone deacetylase 6 | 0.0528 | 0.1113 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.0056 | 0.0045 | 0.0138 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.048 | 0.1006 | 0.9389 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.0054 | 0.004 | 0.0094 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0056 | 0.0045 | 0.0147 |
Plasmodium falciparum | histone deacetylase, putative | 0.0508 | 0.1069 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.048 | 0.1006 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.048 | 0.1006 | 0.9389 |
Plasmodium vivax | histone deacetylase, putative | 0.0508 | 0.1069 | 1 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0056 | 0.0045 | 0.0147 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0508 | 0.1069 | 0.9604 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.048 | 0.1006 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0012 | 0.0116 |
Schistosoma mansoni | N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase | 0.005 | 0.0031 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.0633 | 0.5917 |
Trichomonas vaginalis | histone deacetylase, putative | 0.048 | 0.1006 | 1 |
Leishmania major | udp-glc 4-epimerase, putative | 0.0054 | 0.004 | 0.0094 |
Trypanosoma brucei | histone deacetylase 1 | 0.048 | 0.1006 | 0.9389 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.048 | 0.1006 | 0.9406 |
Loa Loa (eye worm) | histone deacetylase | 0.0508 | 0.1069 | 1 |
Giardia lamblia | Histone deacetylase | 0.048 | 0.1006 | 1 |
Echinococcus granulosus | disco interacting protein 2 | 0.0042 | 0.0012 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.0677 | 0.633 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.048 | 0.1006 | 0.9406 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0508 | 0.1069 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0092 | 0.0126 | 0.0921 |
Plasmodium vivax | histone deacetylase, putative | 0.0193 | 0.0354 | 0.3111 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.048 | 0.1006 | 0.9389 |
Entamoeba histolytica | UDP-glucose 4-epimerase, putative | 0.0056 | 0.0045 | 0.0147 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0193 | 0.0354 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0508 | 0.1069 | 1 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0042 | 0.0012 | 0.0111 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0193 | 0.0354 | 0.3111 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0528 | 0.1113 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.1006 | 0.9406 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.048 | 0.1006 | 1 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0042 | 0.0012 | 0.0116 |
Brugia malayi | UDP galactose 4'-epimerase | 0.0056 | 0.0045 | 0.042 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.0056 | 0.0045 | 0.0404 |
Leishmania major | histone deacetylase, putative | 0.048 | 0.1006 | 0.9389 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.048 | 0.1006 | 0.9406 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0193 | 0.0354 | 0.3111 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.8 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP | ChEMBL. | 16302797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.