Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | caspase 3, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Homo sapiens | caspase 7, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Homo sapiens | caspase 6, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Homo sapiens | caspase 1, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cell death protein 3 precursor | caspase 7, apoptosis-related cysteine peptidase | 303 aa | 256 aa | 37.1 % |
Brugia malayi | Cell death protein 3 precursor | caspase 3, apoptosis-related cysteine peptidase | 277 aa | 253 aa | 38.7 % |
Brugia malayi | Cell death protein 3 precursor | caspase 6, apoptosis-related cysteine peptidase | 293 aa | 270 aa | 34.4 % |
Echinococcus granulosus | caspase 8 | caspase 1, apoptosis-related cysteine peptidase | 383 aa | 312 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | caspase | 0.0293 | 0.3955 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0486 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0293 | 0.3955 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Echinococcus granulosus | caspase 3 | 0.0176 | 0.0263 | 0.0665 |
Brugia malayi | Cell death protein 3 precursor | 0.0167 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Echinococcus multilocularis | caspase | 0.0293 | 0.3955 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0486 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0486 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0486 | 1 | 1 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0293 | 0.3955 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0293 | 0.3955 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0293 | 0.3955 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0486 | 1 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0167 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Echinococcus multilocularis | caspase 3 | 0.0176 | 0.0263 | 0.0665 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0486 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.06 | Inhibition of caspase3 | ChEMBL. | 22503362 |
IC50 (binding) | = 8.8 nM | Inhibitory activity against caspase 3 using Ac-DEVD-AMC substrate | ChEMBL. | 16302804 |
IC50 (binding) | = 8.8 nM | Inhibitory activity against caspase 3 using Ac-DEVD-AMC substrate | ChEMBL. | 16302804 |
IC50 (binding) | = 21 nM | Inhibitory activity against caspase 7 using Ac-DEVD-AMC substrate | ChEMBL. | 16302804 |
IC50 (binding) | = 21 nM | Inhibitory activity against caspase 7 using Ac-DEVD-AMC substrate | ChEMBL. | 16302804 |
IC50 (binding) | > 5000 nM | Inhibitory activity against caspase 6 using Ac-VEID-AMC substrate | ChEMBL. | 16302804 |
IC50 (binding) | > 5000 nM | Inhibitory activity against caspase 6 using Ac-VEID-AMC substrate | ChEMBL. | 16302804 |
IC50 (binding) | > 10000 nM | Inhibitory activity against caspase 1 using Ac-YVAD-AMC substrate | ChEMBL. | 16302804 |
IC50 (binding) | > 10000 nM | Inhibitory activity against caspase 1 using Ac-YVAD-AMC substrate | ChEMBL. | 16302804 |
IC50 (binding) | > 50000 nM | Inhibitory activity against caspase 8 using Ac-IETD-AMC substrate | ChEMBL. | 16302804 |
IC50 (binding) | > 50000 nM | Inhibitory activity against caspase 8 using Ac-IETD-AMC substrate | ChEMBL. | 16302804 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.