Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0222 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0222 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0222 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0222 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0222 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16.1 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP | ChEMBL. | 16302797 |
IC50 (binding) | = 28.7 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma | ChEMBL. | 16302797 |
IC50 (binding) | > 1000 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione | ChEMBL. | 16302797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.