Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Canis lupus familiaris | Cyclooxygenase-2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0405 | 0.4701 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0048 | 0 | 0.5 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0405 | 0.4701 | 0.4701 |
Giardia lamblia | CDC72 | 0.0405 | 0.4701 | 0.5 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0405 | 0.4701 | 0.5 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0405 | 0.4701 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0405 | 0.4701 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0048 | 0 | 0.5 |
Brugia malayi | N-myristoyltransferase 2 | 0.0405 | 0.4701 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.0405 | 0.4701 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0027 | 0.0058 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0027 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0027 | 0.0058 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0405 | 0.4701 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0048 | 0 | 0.5 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0405 | 0.4701 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0048 | 0 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0405 | 0.4701 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0405 | 0.4701 | 0.5 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0027 | 0.0058 |
Leishmania major | N-myristoyl transferase, putative | 0.0405 | 0.4701 | 0.5 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0405 | 0.4701 | 0.5 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0405 | 0.4701 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0048 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.36 uM | Inhibitory activity against COX2 in canine whole blood | ChEMBL. | 16275075 |
IC50 (binding) | = 0.36 uM | Inhibitory activity against COX2 in canine whole blood | ChEMBL. | 16275075 |
IC50 (binding) | = 40.8 uM | Inhibitory activity against COX1 in canine whole blood | ChEMBL. | 16275075 |
IC50 (binding) | = 40.8 uM | Inhibitory activity against COX1 in canine whole blood | ChEMBL. | 16275075 |
Ratio IC50 (binding) | = 113.6 | Selectivity of COX1 over COX2 in canine whole blood assay | ChEMBL. | 16275075 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.