Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.2128 | 0.3026 | 1 |
Loa Loa (eye worm) | subtilase | 0.5683 | 1 | 0.5 |
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.2128 | 0.3026 | 1 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.5683 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 17 % | Inhibition of Plasmodium falciparum CQ-resistant strain FcB1 growth at 1 uM | ChEMBL. | 16263280 |
Inhibition (functional) | = 17 % | Inhibition of Plasmodium falciparum CQ-resistant strain FcB1 growth at 1 uM | ChEMBL. | 16263280 |
MIC80 (functional) | = 1 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 by NCCLS method | ChEMBL. | 25127462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.