Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0732 | 0.2633 | 0.2633 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.168 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.168 | 1 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0732 | 0.2633 | 0.5 |
Onchocerca volvulus | 0.168 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 0.2633 | 0.2633 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0732 | 0.2633 | 0.2633 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0732 | 0.2633 | 0.2633 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0392 | 0 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0732 | 0.2633 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0732 | 0.2633 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0732 | 0.2633 | 0.2633 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0732 | 0.2633 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0732 | 0.2633 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0655 | 0.2037 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0732 | 0.2633 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0392 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.168 | 1 | 1 |
Onchocerca volvulus | 0.152 | 0.8752 | 0.8752 | |
Loa Loa (eye worm) | hypothetical protein | 0.168 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Cytotoxicity in MDCK cells using MTS assay | ChEMBL. | 16216505 |
IC50 (functional) | > 20 uM | Inhibitory activity against influenza A3/beijing/30/95(H1N1) virus in MDCK cells | ChEMBL. | 16216505 |
IC50 (binding) | > 20 uM | Inhibition of Influenza A virus neuraminidase activity | ChEMBL. | 17513019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.