Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0418 | 0.3995 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0418 | 0.3995 | 0.5 |
Giardia lamblia | CDC72 | 0.0418 | 0.3995 | 0.5 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0418 | 0.3995 | 0.5 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0418 | 0.3995 | 0.5 |
Schistosoma mansoni | N-myristoyltransferase | 0.0418 | 0.3995 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0418 | 0.3995 | 1 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0418 | 0.3995 | 0.5 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0418 | 0.3995 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 1 | 1 |
Brugia malayi | N-myristoyltransferase 2 | 0.0418 | 0.3995 | 0.5 |
Leishmania major | N-myristoyl transferase, putative | 0.0418 | 0.3995 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0418 | 0.3995 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0418 | 0.3995 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 465 nM | Displacement of [3H]DPDPE from cloned human delta opioid receptor | ChEMBL. | 16236510 |
Ki (binding) | > 465 nM | Displacement of [3H]DAMGO from cloned human mu opioid receptor | ChEMBL. | 16236510 |
Ki (binding) | > 465 nM | Displacement of [3H]DPDPE from cloned human delta opioid receptor | ChEMBL. | 16236510 |
Ki (binding) | > 465 nM | Displacement of [3H]DAMGO from cloned human mu opioid receptor | ChEMBL. | 16236510 |
Ki (binding) | > 4652 nM | Displacement of [3H]U69593 from cloned human kappa opioid receptor | ChEMBL. | 16236510 |
Ki (binding) | > 4652 nM | Displacement of [3H]U69593 from cloned human kappa opioid receptor | ChEMBL. | 16236510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.