Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0214 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0214 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0214 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0214 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0214 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0214 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0214 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0214 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0214 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0214 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0214 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0214 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0214 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0214 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0214 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0214 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0214 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0214 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0214 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0214 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0214 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0214 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0214 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0214 | 0.5 | 0.5 | |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0214 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0214 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0214 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.39 uM | Cytotoxicity against human lung carcinoma Lu1 cell line | ChEMBL. | 16420055 |
IC50 (functional) | = 2.39 uM | Cytotoxicity against human lung carcinoma Lu1 cell line | ChEMBL. | 16420055 |
IC50 (functional) | = 3.47 uM | Cytotoxicity against human breast carcinoma MCF7 cell line | ChEMBL. | 16420055 |
IC50 (functional) | = 3.47 uM | Cytotoxicity against human breast carcinoma MCF7 cell line | ChEMBL. | 16420055 |
IC50 (functional) | = 4.32 uM | Cytotoxicity against human oral epidermoid carcinoma KB cell line | ChEMBL. | 16420055 |
IC50 (functional) | = 4.32 uM | Cytotoxicity against human prostate carcinoma LNCaP cell line | ChEMBL. | 16420055 |
IC50 (functional) | = 4.32 uM | Cytotoxicity against human oral epidermoid carcinoma KB cell line | ChEMBL. | 16420055 |
IC50 (functional) | = 4.32 uM | Cytotoxicity against human prostate carcinoma LNCaP cell line | ChEMBL. | 16420055 |
IC50 (functional) | = 8.06 uM | Cytotoxicity against human colon carcinoma Col2 cell line | ChEMBL. | 16420055 |
IC50 (functional) | = 8.06 uM | Cytotoxicity against human colon carcinoma Col2 cell line | ChEMBL. | 16420055 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16420055 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.