Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.2868 | 0.5712 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.2868 | 0.5712 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0837 | 0.0946 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.062 | 0.07 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0837 | 0.0232 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0164 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.007 | 0.2977 | 0.2977 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0837 | 0.0232 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.2868 | 0.2397 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.2868 | 0.5712 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.007 | 0.2977 | 0.2977 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0164 | 1 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.2868 | 0.8475 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.8847 | 0.8847 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0164 | 1 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.4763 | 0.4577 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.2868 | 0.2868 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0731 | 0.0878 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0164 | 1 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.3322 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.2868 | 0.5712 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0164 | 1 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.4763 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.062 | 0.0286 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0343 | 0.0343 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0731 | 0.0878 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.2868 | 0.2397 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0164 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.4763 | 1 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.2868 | 0.8475 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0164 | 1 | 0.5 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.2868 | 0.2614 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.2172 | 0.2172 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1422 | 0.1422 |
Brugia malayi | hypothetical protein | 0.0148 | 0.8847 | 0.8806 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.062 | 0.062 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0164 | 1 | 0.5 |
Onchocerca volvulus | 0.0148 | 0.8847 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 100 nM | Displacement of [3H]ZM241385 from Adenosine A2B receptor expressed in HEK cells | ChEMBL. | 16275090 |
Ki (binding) | = 100 nM | Displacement of [3H]ZM241385 from Adenosine A2B receptor expressed in HEK cells | ChEMBL. | 16275090 |
Ki (binding) | = 620 nM | Displacement of [125I]AB-MECA from Adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16275090 |
Ki (binding) | = 620 nM | Displacement of [125I]AB-MECA from Adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16275090 |
Ki (binding) | = 1900 nM | Displacement of [3H]CPX from Adenosine A1 receptor expressed in CHO cells | ChEMBL. | 16275090 |
Ki (binding) | = 1900 nM | Displacement of [3H]CPX from Adenosine A1 receptor expressed in CHO cells | ChEMBL. | 16275090 |
Ki (binding) | > 5000 nM | Displacement of [3H]ZM241385 from Adenosine A2A receptor expressed in HEK cells | ChEMBL. | 16275090 |
Ki (binding) | > 5000 nM | Displacement of [3H]ZM241385 from Adenosine A2A receptor expressed in HEK cells | ChEMBL. | 16275090 |
Ratio Ki (binding) | > 50 | Selectivity of adenosine A2A receptor over adenosine A2B receptor | ChEMBL. | 16275090 |
Ratio Ki (binding) | = 6 | Selectivity of adenosine A3 receptor over adenosine A2B receptor | ChEMBL. | 16275090 |
Ratio Ki (binding) | = 19 | Selectivity of adenosine A1 receptor over adenosine A2B receptor | ChEMBL. | 16275090 |
Ratio Ki (binding) | > 50 | Selectivity of adenosine A2A receptor over adenosine A2B receptor | ChEMBL. | 16275090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.