Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0067 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0067 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0067 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0067 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0067 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0067 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0067 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0067 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0067 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0067 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0067 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0067 | 0.5 | 0.5 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0067 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0067 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0067 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0067 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0067 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0067 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0067 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0067 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0067 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0067 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0067 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0067 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0067 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0067 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0067 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.3 uM | Cytotoxicity against human A549 cell line | ChEMBL. | 16420032 |
IC50 (functional) | = 4.3 uM | Cytotoxicity against human A549 cell line | ChEMBL. | 16420032 |
IC50 (functional) | > 20 uM | Cytotoxicity against human MCF7 cell line | ChEMBL. | 16420032 |
IC50 (functional) | > 20 uM | Cytotoxicity against human MCF7 cell line | ChEMBL. | 16420032 |
MIC99 (functional) | = 5 uM | Antimicrobial activity against Mycobacterium tuberculosis IMCJ946.K2 | ChEMBL. | 16420032 |
MIC99 (functional) | = 5 uM | Antimicrobial activity against Mycobacterium tuberculosis IMCJ946.K2 | ChEMBL. | 16420032 |
MIC99 (functional) | = 20 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 16420032 |
MIC99 (functional) | = 20 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 16420032 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16420032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.