Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 78.6 % | Cytotoxicity against neuroblastoma SHSY5Y cell line by MTT assay at 100 uM | ChEMBL. | 16420033 |
Activity (functional) | = 78.6 % | Cytotoxicity against neuroblastoma SHSY5Y cell line by MTT assay at 100 uM | ChEMBL. | 16420033 |
Activity (functional) | = 88.2 % | Cytotoxicity against human pancreatic carcinoma FG2 cell line by MTT assay at 100 uM | ChEMBL. | 16420033 |
Activity (functional) | = 88.2 % | Cytotoxicity against human pancreatic carcinoma FG2 cell line by MTT assay at 100 uM | ChEMBL. | 16420033 |
Activity (functional) | = 93.2 % | Cytotoxicity against breast cancer MDA-MB-231 cell line by MTT assay at 100 uM | ChEMBL. | 16420033 |
Activity (functional) | = 93.2 % | Cytotoxicity against breast cancer MDA-MB-231 cell line by MTT assay at 100 uM | ChEMBL. | 16420033 |
Activity (functional) | = 116 % | Cytotoxicity against basophilic leukemia RBL 2H3 cell line by MTT assay at 100 uM | ChEMBL. | 16420033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.