Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0247 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0096 | 0.3608 | 0.5 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0247 | 1 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0247 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0096 | 0.3608 | 0.5 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0096 | 0.3608 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0247 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 | Inhibition of isomerase activity of Cyclophilin A | ChEMBL. | 16451056 |
Inhibition (binding) | = 44 % | Inhibition of isomerase activity of Cyclophilin A at 10 uM | ChEMBL. | 16451056 |
Inhibition (binding) | = 44 % | Inhibition of isomerase activity of Cyclophilin A at 10 uM | ChEMBL. | 16451056 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.