Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | lanosterol synthase, putative | 0.1425 | 1 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.1425 | 1 | 1 |
Leishmania major | lanosterol synthase, putative | 0.1314 | 0.9029 | 1 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0857 | 0.5014 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.51 uM | Inhibition of 17beta HSD1 in T47D cells | ChEMBL. | 16480268 |
Inhibition (functional) | < 10 % | Inhibition of 17beta HSD2 in MDA-MB231cells at 10 uM | ChEMBL. | 16480268 |
Inhibition (functional) | = 91 % | Inhibition of 17beta HSD1 in T47D cells at 10 uM | ChEMBL. | 16480268 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.