Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | DNA polymerase III polC-type | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.1046 | 1 | 1 |
Mycobacterium ulcerans | error-prone DNA polymerase | 0.0294 | 0.1345 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) | 0.0294 | 0.1345 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1046 | 1 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) | 0.0294 | 0.1345 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0177 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1046 | 1 | 1 |
Treponema pallidum | DNA polymerase III subunit alpha | 0.0294 | 0.1345 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1046 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1046 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1046 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1046 | 1 | 1 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1046 | 1 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) | 0.0294 | 0.1345 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1046 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1046 | 1 | 1 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1046 | 1 | 1 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0177 | 0 | 0.5 |
Chlamydia trachomatis | DNA polymerase III subunit alpha | 0.0294 | 0.1345 | 0.5 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III alpha subunit | 0.0294 | 0.1345 | 0.5 |
Mycobacterium ulcerans | DNA polymerase III subunit alpha | 0.0294 | 0.1345 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Cytotoxicity against HeLa cell line by MTS assay | ChEMBL. | 16298129 |
Activity (functional) | 0 | Decrease in ATP productions in human hepatocytes at 100 uM | ChEMBL. | 16298129 |
IC50 (binding) | = 3 uM | Inhibition of DNA polymerase3C from Staphylococcus aureus | ChEMBL. | 16298129 |
IC50 (binding) | = 3 uM | Inhibition of DNA polymerase3C from Staphylococcus aureus | ChEMBL. | 16298129 |
Inhibition (binding) | = 75 % | Inhibition of DNA polymerase3C from Staphylococcus aureus at 100 uM | ChEMBL. | 16298129 |
Inhibition (binding) | = 75 % | Inhibition of DNA polymerase3C from Staphylococcus aureus at 100 uM | ChEMBL. | 16298129 |
MIC (functional) | = 8 ug ml-1 | Antimicrobial activity against Staphylococcus aureus (RN4220) | ChEMBL. | 16298129 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.