Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0411 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0411 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0411 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0411 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0411 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0411 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0411 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0411 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0411 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0411 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Block (functional) | = 0 % | Tested for anticonvulsant activity against mice at 4 hr at a peroral dose of 75 mg/Kg by maximal electroshock seizure (MES) test | ChEMBL. | No reference |
Block (functional) | = 0 % | Tested for anticonvulsant activity against mice at 4 hr at a peroral dose of 300 mg/Kg by maximal electroshock seizure (MES) test | ChEMBL. | No reference |
Block (functional) | = 0 % | Activity against maximal electroshock seizures in mice, 4 hr following oral administration of 300 mg/kg of compound | ChEMBL. | 9548821 |
Block (functional) | = 0 % | Tested for anticonvulsant activity against mice at 4 hr at a peroral dose of 75 mg/Kg by maximal electroshock seizure (MES) test | ChEMBL. | No reference |
Block (functional) | = 0 % | Tested for anticonvulsant activity against mice at 4 hr at a peroral dose of 300 mg/Kg by maximal electroshock seizure (MES) test | ChEMBL. | No reference |
Block (functional) | = 0 % | Activity against maximal electroshock seizures in mice, 4 hr following oral administration of 300 mg/kg of compound | ChEMBL. | 9548821 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.