Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | GMP reductase | 0.00824249 | 0.399952 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.00824249 | 0.399952 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0152921 | 1 | 1 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.00824249 | 0.399952 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.00824249 | 0.399952 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0152921 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.00824249 | 0.399952 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.00824249 | 0.399952 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0152921 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.00824249 | 0.399952 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.00782779 | 0.364654 | 0.903202 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.00824249 | 0.399952 | 0.5 |
Toxoplasma gondii | IMP dehydrogenas | 0.00824249 | 0.399952 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.00824249 | 0.399952 | 0.399952 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.00782779 | 0.364654 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.00824249 | 0.399952 | 0.5 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.00782779 | 0.364654 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.00428413 | 0.0630267 | 0.076042 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.00824249 | 0.399952 | 0.399952 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.00824249 | 0.399952 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.00824249 | 0.399952 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0152921 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0152921 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0152921 | 1 | 1 |
Trypanosoma brucei | GMP reductase | 0.00824249 | 0.399952 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0152921 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.00824249 | 0.399952 | 0.5 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0152921 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 160 nM | In vitro for inhibition of parasite development of Plasmodium falciparum (W-2 strain) cultured in human erythrocytes in an antiparasitic assay | ChEMBL. | 11992775 |
IC50 (functional) | = 160 nM | In vitro for inhibition of parasite development of Plasmodium falciparum (W-2 strain) cultured in human erythrocytes in an antiparasitic assay | ChEMBL. | 11992775 |
IC50 (functional) | = 360 nM | In vitro for antimalarial activity against Plasmodium falciparum (W-2 strain) cultured in human erythrocytes by the inhibition of [3H]-hypoxanthine uptake | ChEMBL. | 11992775 |
IC50 (functional) | = 360 nM | In vitro for antimalarial activity against Plasmodium falciparum (W-2 strain) cultured in human erythrocytes by the inhibition of [3H]-hypoxanthine uptake | ChEMBL. | 11992775 |
IC50 (functional) | = 530 nM | In vitro for inhibition of parasite development of Plasmodium falciparum (W-2 strain) cultured in human erythrocytes in an antiparasitic assay | ChEMBL. | 11992775 |
IC50 (functional) | = 530 nM | In vitro for inhibition of parasite development of Plasmodium falciparum (W-2 strain) cultured in human erythrocytes in an antiparasitic assay | ChEMBL. | 11992775 |
IC50 (functional) | = 800 nM | In vitro for antimalarial activity against Plasmodium falciparum (W-2 strain) cultured in human erythrocytes by the inhibition of [3H]-hypoxanthine uptake | ChEMBL. | 11992775 |
IC50 (functional) | = 800 nM | In vitro for antimalarial activity against Plasmodium falciparum (W-2 strain) cultured in human erythrocytes by the inhibition of [3H]-hypoxanthine uptake | ChEMBL. | 11992775 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11992775 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.