Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0263 | 0.2575 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0344 | 0.3984 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0263 | 0.2575 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0344 | 0.3984 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0229 | 0.1977 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0263 | 0.2575 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.069 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.069 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.069 | 1 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.069 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.021 | 0.1648 | 1 |
Plasmodium falciparum | peptide deformylase | 0.069 | 1 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0263 | 0.2575 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.021 | 0.1648 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.021 | 0.1648 | 0.8334 |
Treponema pallidum | polypeptide deformylase (def) | 0.069 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0329 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.069 | 1 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0263 | 0.2575 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.069 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0229 | 0.1977 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0263 | 0.2575 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0263 | 0.2575 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0134 | 0.0329 | 0.1666 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40 uM | Inhibitory activity against rhinovirus type 1B | ChEMBL. | 2158561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.