Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 19 | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Loa Loa (eye worm) | cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | cytochrome P450, family 2, subfamily C, polypeptide 19 | 490 aa | 411 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.0086 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0086 | 0.0086 |
Onchocerca volvulus | 0.0032 | 0.0086 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.0086 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.0086 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 1 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0032 | 0.0086 | 0.0086 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.0086 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0086 | 0.0086 |
Echinococcus multilocularis | peroxidasin | 0.0032 | 0.0086 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Onchocerca volvulus | 0.0032 | 0.0086 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0086 | 0.0086 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0086 | 0.0086 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0.0086 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0.0086 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Brugia malayi | Blistered cuticle protein 3 | 0.0032 | 0.0086 | 0.0086 |
Echinococcus granulosus | peroxidasin | 0.0032 | 0.0086 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.0086 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.0086 | 0.5 |
Brugia malayi | Peroxidasin | 0.0032 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0086 | 0.0086 |
Onchocerca volvulus | 0.0032 | 0.0086 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0086 | 0.0086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Activity at CRTh2 measured as calcium flux changes in HEK293 cells by FLIPR | ChEMBL. | 16753296 | |
Activity (functional) | Agonist activity at CRTh2 receptor | ChEMBL. | 16753296 | |
Activity (functional) | 0 | Activity at CRTh2 measured as calcium flux changes in HEK293 cells by FLIPR | ChEMBL. | 16753296 |
Activity (functional) | 0 | Agonist activity at CRTh2 receptor | ChEMBL. | 16753296 |
Activity (binding) | <= 6 uM | Binding affinity to hERG in HEK293 cells by radioligand binding assay | ChEMBL. | 16753296 |
Activity (binding) | <= 6 uM | Binding affinity to DP1 receptor in HEK293 cells by radioligand binding assay | ChEMBL. | 16753296 |
Activity (binding) | <= 6 uM | Binding affinity to hERG in HEK293 cells by radioligand binding assay | ChEMBL. | 16753296 |
Activity (binding) | <= 6 uM | Binding affinity to DP1 receptor in HEK293 cells by radioligand binding assay | ChEMBL. | 16753296 |
CL (ADMET) | = 11 ml/min.kg | Clearance in rat | ChEMBL. | 16753296 |
CL (ADMET) | = 1.4 uL/min | Intrinsic clearance in human hepatocytes per 10^6 cells | ChEMBL. | 16753296 |
CL (ADMET) | = 6.5 uL/min | Intrinsic clearance in rat hepatocytes per 10^6 cells | ChEMBL. | 16753296 |
F (ADMET) | = 62 % | Bioavailability in rat | ChEMBL. | 16753296 |
IC50 (functional) | = 40 nM | Inhibition of COX1-mediated platelet aggregation | ChEMBL. | 16753296 |
IC50 (functional) | = 40 nM | Inhibition of COX1-mediated platelet aggregation | ChEMBL. | 16753296 |
IC50 (binding) | = 180 nM | Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cells | ChEMBL. | 16753296 |
IC50 (binding) | = 180 nM | Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cells | ChEMBL. | 16753296 |
IC50 (ADMET) | = 1.6 uM | Inhibition at recombinant human CYP2C19 | ChEMBL. | 16753296 |
IC50 (ADMET) | = 1.6 uM | Inhibition at recombinant human CYP2C19 | ChEMBL. | 16753296 |
Log D | = 1.7 | Lipophilicity, LogD of the compound at pH 7.4 | ChEMBL. | 16753296 |
PPB (ADMET) | = 99 % | Protein binding in human plasma | ChEMBL. | 16753296 |
T1/2 (ADMET) | = 2.2 hr | Half life in rat | ChEMBL. | 16753296 |
Vss (ADMET) | = 2.3 L/Kg | Volume of distribution in rat | ChEMBL. | 16753296 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.