Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0083 | 0.0597 | 0.0612 |
Toxoplasma gondii | dgat2l1-prov protein | 0.0162 | 0.1528 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.201 | 0.2058 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0162 | 0.1528 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0135 | 0.1211 | 0.0653 |
Onchocerca volvulus | 0.023 | 0.2342 | 1 | |
Entamoeba histolytica | type A flavoprotein, putative | 0.0052 | 0.022 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 0.9766 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 0.9766 | 1 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0052 | 0.022 | 0.1258 |
Schistosoma mansoni | diacylglycerol O-acyltransferase | 0.0036 | 0.0032 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0182 | 0.0186 |
Brugia malayi | flavodoxin family protein | 0.0052 | 0.022 | 0.0226 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0135 | 0.1211 | 0.7883 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0855 | 0.9766 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1211 | 0.124 |
Trypanosoma cruzi | p450 reductase, putative | 0.0135 | 0.1211 | 0.7883 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.012 | 0.1029 | 0.381 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0135 | 0.1211 | 0.7883 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0855 | 0.9766 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.012 | 0.1029 | 0.8159 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0052 | 0.022 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0135 | 0.1211 | 0.7883 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0135 | 0.1211 | 0.467 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.201 | 0.2058 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0162 | 0.1528 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase | 0.0036 | 0.0032 | 0.021 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0135 | 0.1211 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0135 | 0.1211 | 0.7883 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0083 | 0.0597 | 0.391 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0135 | 0.1211 | 0.7883 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0182 | 0.0186 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0067 | 0.0403 | 0.2636 |
Chlamydia trachomatis | sulfite reductase | 0.0083 | 0.0597 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0162 | 0.1528 | 0.1564 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0068 | 0.0415 | 0.2716 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0135 | 0.1211 | 0.124 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.2342 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0067 | 0.0403 | 0.2478 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0052 | 0.022 | 0.1258 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0162 | 0.1528 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0052 | 0.022 | 0.0226 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0052 | 0.022 | 0.5 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0052 | 0.022 | 0.1258 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0135 | 0.1211 | 0.7883 |
Brugia malayi | Serotonin receptor | 0.0498 | 0.5521 | 0.5653 |
Treponema pallidum | flavodoxin | 0.0052 | 0.022 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0135 | 0.1211 | 0.7883 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0875 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0135 | 0.1211 | 0.124 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0052 | 0.022 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0067 | 0.0403 | 0.2478 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0135 | 0.1211 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.012 | 0.1029 | 0.6663 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0135 | 0.1211 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0135 | 0.1211 | 0.0653 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0052 | 0.022 | 0.5 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0162 | 0.1528 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0182 | 0.0186 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0135 | 0.1211 | 0.7927 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0083 | 0.0597 | 0.0612 |
Giardia lamblia | Hypothetical protein | 0.012 | 0.1029 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0135 | 0.1211 | 0.0653 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0032 | 0.021 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.012 | 0.1029 | 0.5 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0052 | 0.022 | 0.1258 |
Brugia malayi | FAD binding domain containing protein | 0.0135 | 0.1211 | 0.124 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0162 | 0.1528 | 1 |
Leishmania major | p450 reductase, putative | 0.0135 | 0.1211 | 0.7883 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0.022 | 0.1258 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0182 | 0.0186 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0135 | 0.1211 | 0.7883 |
Brugia malayi | diacylglycerol acyltransferase family protein | 0.0162 | 0.1528 | 0.1564 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0135 | 0.1211 | 0.0653 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 50 uM | Antiproliferative activity against human HeLa cells by SRB assay | ChEMBL. | 17482817 |
GI50 (functional) | > 50 uM | Antiproliferative activity against human HOS cells by SRB assay | ChEMBL. | 17482817 |
GI50 (functional) | > 50 uM | Antiproliferative activity against human HeLa cells by SRB assay | ChEMBL. | 17482817 |
GI50 (functional) | > 50 uM | Antiproliferative activity against human HOS cells by SRB assay | ChEMBL. | 17482817 |
IC50 (functional) | 0 | Antiproliferative activity against human HL60 cells by MTT assay | ChEMBL. | 16765045 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.