Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0328 | 0 | 0.5 | |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0328 | 0 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.1704 | 1 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0328 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0468 | 0.1021 | 0.1021 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0825 | 0.3616 | 0.5 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0328 | 0 | 0.5 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0328 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0825 | 0.3616 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1704 | 1 | 1 |
Toxoplasma gondii | dgat2l1-prov protein | 0.0328 | 0 | 0.5 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0328 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1704 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 38 % | Antagonist activity assessed as inhibition of estrogen-stimulated uterine weight gain in overiectomized mouse at 3 mg/kg, po | ChEMBL. | 16709454 |
Inhibition (functional) | = 38 % | Antagonist activity assessed as inhibition of estrogen-stimulated uterine weight gain in overiectomized mouse at 3 mg/kg, po | ChEMBL. | 16709454 |
Inhibition (functional) | = 85 % | Antagonist activity assessed as inhibition of estrogen-stimulated uterine weight gain in overiectomized mouse at 10 mg/kg, po | ChEMBL. | 16709454 |
Inhibition (functional) | = 85 % | Antagonist activity assessed as inhibition of estrogen-stimulated uterine weight gain in overiectomized mouse at 10 mg/kg, po | ChEMBL. | 16709454 |
Inhibition (functional) | = 99 % | Antagonist activity assessed as inhibition of estrogen-stimulated uterine weight gain in overiectomized mouse at 30 mg/kg, po | ChEMBL. | 16709454 |
Inhibition (functional) | = 99 % | Antagonist activity assessed as inhibition of estrogen-stimulated uterine weight gain in overiectomized mouse at 30 mg/kg, po | ChEMBL. | 16709454 |
RBA (binding) | = 0.3 % | Displacement of [3H]estradiol from human recombinant ERalpha relative to estradiol | ChEMBL. | 16709454 |
RBA (binding) | = 0.3 % | Displacement of [3H]estradiol from human recombinant ERalpha relative to estradiol | ChEMBL. | 16709454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.