Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geranylgeranyl diphosphate synthase 1 | Starlite/ChEMBL | References |
Saccharomyces cerevisiae | farnesyltranstransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | geranylgeranyl diphosphate synthase 1 | 300 aa | 317 aa | 21.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0255 | 0.5 | 0.5 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0255 | 0.5 | 0.5 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0255 | 0.5 | 0.5 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0255 | 0.5 | 0.5 |
Leishmania major | polyprenyl synthase, putative | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.0255 | 0.5 | 0.5 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0255 | 0.5 | 0.5 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0255 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.7 | Inhibition of human recombinant geranylgeranyl diphosphate synthase | ChEMBL. | 18800762 |
IC50 (binding) | = 0.07 uM | Inhibition of Saccharomyces cerevisiae GGPPS | ChEMBL. | 17535895 |
IC50 (binding) | = 0.07 uM | Inhibition of Saccharomyces cerevisiae GGPPS | ChEMBL. | 17535895 |
IC50 (binding) | = 0.43 uM | Inhibition of Escherichia coli OPPS | ChEMBL. | 17535895 |
IC50 (binding) | = 0.46 uM | Inhibition of Sulfolobus solfataricus HPPS | ChEMBL. | 17535895 |
IC50 (binding) | = 0.69 uM | Inhibition of Escherichia coli UPPS | ChEMBL. | 17535895 |
IC50 (binding) | = 2.1 uM | Inhibition of human GGPPS | ChEMBL. | 17535895 |
IC50 (binding) | = 2.1 uM | Inhibition of human GGPPS | ChEMBL. | 17535895 |
IC50 (binding) | = 2.14 uM | Inhibition of human recombinant geranylgeranyl diphosphate synthase | ChEMBL. | 18800762 |
IC50 (functional) | = 130 uM | Antiproliferative activity against human SF-268 cell line by MTT assay | ChEMBL. | 16970405 |
IC50 (functional) | = 130 uM | Antiproliferative activity against human SF-268 cell line by MTT assay | ChEMBL. | 16970405 |
IC50 (functional) | = 140 uM | Antiproliferative activity against human NCI-H460 cell line by MTT assay | ChEMBL. | 16970405 |
IC50 (functional) | = 140 uM | Antiproliferative activity against human NCI-H460 cell line by MTT assay | ChEMBL. | 16970405 |
IC50 (functional) | = 152 uM | Antiproliferative activity against human MCF7 cell line by MTT assay | ChEMBL. | 16970405 |
IC50 (functional) | = 152 uM | Antiproliferative activity against human MCF7 cell line by MTT assay | ChEMBL. | 16970405 |
Ki (binding) | = 0.03 uM | Binding affinity to Saccharomyces cerevisiae GGPPS | ChEMBL. | 17535895 |
Ki (binding) | = 0.03 uM | Binding affinity to Saccharomyces cerevisiae GGPPS | ChEMBL. | 17535895 |
Ki (binding) | = 0.06 uM | Binding affinity to human GGPPS | ChEMBL. | 17535895 |
Ki (binding) | = 0.06 uM | Binding affinity to human GGPPS | ChEMBL. | 17535895 |
Log IC50 (binding) | = 6.2 | Inhibition of Escherichia coli UPPS | ChEMBL. | 17535895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.