Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein C (inactivator of coagulation factors Va and VIIIa) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus multilocularis | enteropeptidase | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus granulosus | glycoprotein Antigen 5 | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus multilocularis | glycoprotein Antigen 5 | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus multilocularis | Mastin | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus granulosus | Mastin | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Echinococcus granulosus | enteropeptidase | Get druggable targets OG5_136757 | All targets in OG5_136757 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0049 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0049 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0049 | 1 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0049 | 1 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0049 | 1 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0049 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0016 | 0 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.0016 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.07 uM | Inhibition of human aPC | ChEMBL. | 16913694 |
IC50 (binding) | = 1.07 uM | Inhibition of human aPC | ChEMBL. | 16913694 |
IC50 (binding) | = 1.14 uM | Inhibition of human aPC | ChEMBL. | 16913694 |
IC50 (binding) | = 1.14 uM | Inhibition of human aPC | ChEMBL. | 16913694 |
IC50 (binding) | = 300 uM | Inhibition of human thrombin activity | ChEMBL. | 16913694 |
IC50 (binding) | = 300 uM | Inhibition of human thrombin activity | ChEMBL. | 16913694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.