Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.1252 | 0.1252 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0081 | 0.2901 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0081 | 0.2901 | 0.2368 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0081 | 0.2901 | 0.2368 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.1252 | 0.0595 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0081 | 0.2901 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0058 | 0.1252 | 0.0595 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0071 | 0.2246 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.4051 | 0.3604 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0081 | 0.2901 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0081 | 0.2901 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0081 | 0.2901 | 1 |
Leishmania major | p450 reductase, putative | 0.0081 | 0.2901 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2901 | 0.2368 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0081 | 0.2901 | 0.2368 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.4051 | 0.4051 |
Chlamydia trachomatis | sulfite reductase | 0.005 | 0.0698 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Echinococcus multilocularis | 0.0056 | 0.1123 | 0.0456 | |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0081 | 0.2901 | 0.2368 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.4051 | 0.4051 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3978 | 0.3978 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.1252 | 0.0595 |
Giardia lamblia | Hypothetical protein | 0.0071 | 0.2246 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.4051 | 0.3604 |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.1252 | 0.0595 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.004 | 0 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.005 | 0.0698 | 0.0698 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.1252 | 0.0595 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.4051 | 0.3604 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.1252 | 0.0595 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3978 | 0.3978 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0081 | 0.2901 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0081 | 0.2901 | 1 |
Brugia malayi | flavodoxin family protein | 0.0081 | 0.2901 | 0.2368 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0081 | 0.2901 | 0.2901 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0081 | 0.2901 | 0.2368 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0041 | 0.0044 | 0.0044 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3978 | 0.3978 |
Brugia malayi | FAD binding domain containing protein | 0.0081 | 0.2901 | 0.2368 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.1252 | 0.1252 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.2 uM | Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay | ChEMBL. | 16887347 |
IC50 (functional) | = 8.2 uM | Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay | ChEMBL. | 16887347 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.