Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0041 | 0.0044 | 0.0044 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0081 | 0.2901 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0081 | 0.2901 | 0.2368 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0081 | 0.2901 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0081 | 0.2901 | 0.2901 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0081 | 0.2901 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.004 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.1252 | 0.1252 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0081 | 0.2901 | 0.2368 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.1252 | 0.0595 |
Echinococcus multilocularis | 0.0056 | 0.1123 | 0.0456 | |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.1252 | 0.0595 |
Giardia lamblia | Hypothetical protein | 0.0071 | 0.2246 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0081 | 0.2901 | 0.2368 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.005 | 0.0698 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0081 | 0.2901 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0081 | 0.2901 | 0.2368 |
Brugia malayi | FAD binding domain containing protein | 0.0081 | 0.2901 | 0.2368 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0081 | 0.2901 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0081 | 0.2901 | 0.2368 |
Leishmania major | p450 reductase, putative | 0.0081 | 0.2901 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.004 | 0 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.1252 | 0.0595 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3978 | 0.3978 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.005 | 0.0698 | 0.0698 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.1252 | 0.1252 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3978 | 0.3978 |
Brugia malayi | flavodoxin family protein | 0.0081 | 0.2901 | 0.2368 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3978 | 0.3978 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2901 | 0.2368 |
Trypanosoma cruzi | p450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0081 | 0.2901 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0081 | 0.2901 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 1 | 1 |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.1252 | 0.0595 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.4051 | 0.4051 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.4051 | 0.3604 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.4051 | 0.3604 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0058 | 0.1252 | 0.0595 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.4051 | 0.4051 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0081 | 0.2901 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0071 | 0.2246 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.1252 | 0.0595 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.4051 | 0.3604 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.2 uM | Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay | ChEMBL. | 16887347 |
IC50 (functional) | = 8.2 uM | Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay | ChEMBL. | 16887347 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.