Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Oryctolagus cuniculus | Glycogen phosphorylase, muscle form | Starlite/ChEMBL | References |
Rattus norvegicus | Liver glycogen phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Glycogen phosphorylase, muscle form | 843 aa | 840 aa | 70.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycogen phosphorylase | 0.0391 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0391 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0391 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0391 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0391 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0391 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0391 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0391 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0391 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0391 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0391 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0391 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0391 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0391 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0391 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0391 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of phosphorylated form of rabbit muscle glycogen phosphorylase | ChEMBL. | 16970395 | |
IC50 (binding) | 0 | Inhibition of phosphorylated form of rabbit muscle glycogen phosphorylase | ChEMBL. | 16970395 |
IC50 (binding) | = 0.84 uM | Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase | ChEMBL. | 16970395 |
IC50 (binding) | = 0.84 uM | Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase | ChEMBL. | 16970395 |
IC50 (binding) | = 0.85 uM | Inhibition of phosphorylated form of pig liver glycogen phosphorylase | ChEMBL. | 16970395 |
IC50 (binding) | = 0.85 uM | Inhibition of phosphorylated form of pig liver glycogen phosphorylase | ChEMBL. | 16970395 |
IC50 (binding) | = 1.22 uM | Inhibition of phosphorylated form of rat liver glycogen phosphorylase | ChEMBL. | 16970395 |
IC50 (binding) | = 1.22 uM | Inhibition of phosphorylated form of rat liver glycogen phosphorylase | ChEMBL. | 16970395 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.