Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0069 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0069 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0069 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0069 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0069 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0069 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0069 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0069 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0069 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0069 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0069 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0069 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0069 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0069 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0069 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0069 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0069 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0069 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0069 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0069 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0069 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0069 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0069 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0069 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 58.1 uM | Antiproliferative activity against human NCI-H460 cell line by MTT assay | ChEMBL. | 16970405 |
IC50 (functional) | = 58.1 uM | Antiproliferative activity against human NCI-H460 cell line by MTT assay | ChEMBL. | 16970405 |
IC50 (functional) | = 58.3 uM | Antiproliferative activity against human SF-268 cell line by MTT assay | ChEMBL. | 16970405 |
IC50 (functional) | = 58.3 uM | Antiproliferative activity against human SF-268 cell line by MTT assay | ChEMBL. | 16970405 |
IC50 (functional) | = 121 uM | Antiproliferative activity against human MCF7 cell line by MTT assay | ChEMBL. | 16970405 |
IC50 (functional) | = 121 uM | Antiproliferative activity against human MCF7 cell line by MTT assay | ChEMBL. | 16970405 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.