Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.0101 | 0.0917 | 0.5 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.0271 | 1 | 0.5 |
Loa Loa (eye worm) | subtilase | 0.0271 | 1 | 1 |
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.0101 | 0.0917 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 22.5 uM | Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay | ChEMBL. | 16970401 |
IC50 (functional) | = 22.5 uM | Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay | ChEMBL. | 16970401 |
IC50 (functional) | > 100 uM | Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay | ChEMBL. | 16970401 |
IC50 (functional) | > 100 uM | Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay | ChEMBL. | 16970401 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.