Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0681 | 0.1583 | 0.321 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.12 | 0.665 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.1264 | 0.7279 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1264 | 0.7279 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1264 | 0.7279 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.12 | 0.665 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1264 | 0.7279 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1264 | 0.7279 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1264 | 0.7279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1543 | 1 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1264 | 0.7279 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1264 | 0.7279 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1543 | 1 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1264 | 0.7279 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1264 | 0.7279 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1264 | 0.7279 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1024 | 0.4933 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1264 | 0.7279 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 33 umol/Kg | Anticonvulsant activity against tonic phase of audiogenic seizures in ip dosed DBA/2 mouse | ChEMBL. | 16942035 |
ED50 (functional) | = 33 umol/Kg | Anticonvulsant activity against tonic phase of audiogenic seizures in ip dosed DBA/2 mouse | ChEMBL. | 16942035 |
ED50 (functional) | = 44.5 umol/Kg | Anticonvulsant activity against clonic phase of audiogenic seizures in ip dosed DBA/2 mouse | ChEMBL. | 16942035 |
ED50 (functional) | = 44.5 umol/Kg | Anticonvulsant activity against clonic phase of audiogenic seizures in ip dosed DBA/2 mouse | ChEMBL. | 16942035 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.