Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, AMPA 4 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, AMPA 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | glutamate receptor, ionotropic, AMPA 2 | 883 aa | 810 aa | 34.0 % |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | glutamate receptor, ionotropic, AMPA 4 | 902 aa | 818 aa | 33.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0072 | 0.1012 | 0.1012 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0072 | 0.1012 | 1 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0124 | 0.5626 | 0.5626 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.3651 | 0.4062 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0163 | 0.8988 | 0.5 |
Echinococcus granulosus | glutamate receptor 4 | 0.0102 | 0.3651 | 0.3651 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0163 | 0.8988 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0072 | 0.1012 | 0.1012 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0072 | 0.1012 | 0.1012 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0174 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0072 | 0.1012 | 0.1012 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0174 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0102 | 0.3651 | 0.3651 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0163 | 0.8988 | 0.8988 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0163 | 0.8988 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0152 | 0.8025 | 0.8025 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0174 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0072 | 0.1012 | 0.1012 |
Echinococcus granulosus | glutamate receptor 1 | 0.0102 | 0.3651 | 0.3651 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0072 | 0.1012 | 0.1012 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0124 | 0.5626 | 0.5626 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.3651 | 0.4062 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.3651 | 0.4062 |
Echinococcus granulosus | glutamate receptor 2 | 0.0152 | 0.8025 | 0.8025 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 42 nM | Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | = 42 nM | Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | = 55 nM | Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | = 55 nM | Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | = 157 nM | Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | = 157 nM | Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | = 225 nM | Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | = 225 nM | Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.