Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 131 nM | Antagonist activity against capsaicin-activated human VR1 by FLIPR assay | ChEMBL. | 16870426 |
IC50 (functional) | = 131 nM | Antagonist activity against capsaicin-activated human VR1 by FLIPR assay | ChEMBL. | 16870426 |
IC50 (functional) | = 348 nM | Antagonist activity against low pH(5.0-5.5)-activated rat VR1 | ChEMBL. | 16870426 |
IC50 (functional) | = 348 nM | Antagonist activity against low pH(5.0-5.5)-activated rat VR1 | ChEMBL. | 16870426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.