Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, AMPA 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | glutamate receptor, ionotropic, AMPA 4 | 902 aa | 818 aa | 33.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Ribonuclease H | 0.0344 | 0.249 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0373 | 0.2722 | 0.0309 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0373 | 0.2722 | 0.0309 |
Trypanosoma brucei | unspecified product | 0.0373 | 0.2722 | 0.0309 |
Schistosoma mansoni | phosphoglucomutase | 0.0344 | 0.249 | 0.249 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.0046 | 0.0183 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0081 | 0.0405 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0344 | 0.249 | 0.5 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0344 | 0.249 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0344 | 0.249 | 0.249 |
Leishmania major | ribonuclease H1, putative | 0.0344 | 0.249 | 0.5 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0344 | 0.249 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.0046 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0164 | 0.4062 |
Brugia malayi | RNase H family protein | 0.0344 | 0.249 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.0046 | 0.0183 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0051 | 0.0164 | 0.066 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0373 | 0.2722 | 0.0309 |
Echinococcus granulosus | glutamate receptor 1 | 0.0051 | 0.0164 | 0.066 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0373 | 0.2722 | 0.0309 |
Echinococcus granulosus | glutamate receptor 4 | 0.0051 | 0.0164 | 0.066 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0087 | 0.045 | 0.1809 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0087 | 0.045 | 0.1809 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0344 | 0.249 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.0046 | 0.0183 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0036 | 0.0046 | 0.0046 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0344 | 0.249 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0076 | 0.0362 | 0.1452 |
Trypanosoma brucei | RNA helicase, putative | 0.129 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0164 | 0.4062 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0076 | 0.0362 | 0.1452 |
Schistosoma mansoni | phosphoglucomutase | 0.0344 | 0.249 | 0.249 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.0046 | 0.0183 |
Brugia malayi | RNase H family protein | 0.0344 | 0.249 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0081 | 0.0405 | 0.1626 |
Echinococcus multilocularis | ribonuclease H1 | 0.0344 | 0.249 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.0046 | 0.0183 |
Toxoplasma gondii | ribonuclease HI protein | 0.0344 | 0.249 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0087 | 0.045 | 0.1809 |
Brugia malayi | RNase H family protein | 0.0344 | 0.249 | 1 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0062 | 0.0253 | 0.1018 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0087 | 0.045 | 0.1809 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0344 | 0.249 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0164 | 0.4062 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0062 | 0.0253 | 0.1018 |
Echinococcus granulosus | ribonuclease H1 | 0.0344 | 0.249 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 | |
EC50 (functional) | Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 | |
EC50 (functional) | Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 | |
EC50 (functional) | 0 | Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | 0 | Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | 0 | Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | = 619 nM | Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
EC50 (functional) | = 619 nM | Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay | ChEMBL. | 16872827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.