Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 91 nM | Antagonist activity against capsaicin-activated human VR1 by FLIPR assay | ChEMBL. | 16870426 |
IC50 (functional) | = 91 nM | Antagonist activity against capsaicin-activated human VR1 by FLIPR assay | ChEMBL. | 16870426 |
IC50 (functional) | = 166 nM | Antagonist activity against low pH(5.0-5.5)-activated rat VR1 | ChEMBL. | 16870426 |
IC50 (functional) | = 166 nM | Antagonist activity against low pH(5.0-5.5)-activated rat VR1 | ChEMBL. | 16870426 |
Solubility | = 1 ug ml-1 | Aqueous solubility at pH 7.4 by HTsol assay | ChEMBL. | 16870426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.