Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.5362 | 1 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.5362 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.0234 | 0.0231 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0075 | 0.0072 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.2089 | 0.3832 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.0234 | 0.0231 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.5362 | 1 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.2089 | 0.3832 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0003 | 0.0003 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0077 | 0.0074 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.0234 | 0.0231 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0075 | 0.0072 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.0077 | 0.0074 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.0234 | 0.0231 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0077 | 0.0074 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.0077 | 0.0077 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0075 | 0.0072 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0003 | 0.0003 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.2089 | 0.3832 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.5362 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.0077 | 0.0074 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fu (ADMET) | = 8.6 % | Free drug level in rat plasma at 37 degC | ChEMBL. | 16806916 |
IC50 (binding) | = 9 nM | Inhibition of EGFR | ChEMBL. | 16806916 |
IC50 (binding) | = 9 nM | Inhibition of EGFR | ChEMBL. | 16806916 |
IC50 (functional) | = 58 nM | Antiproliferative activity against EGF-stimulated KB cells | ChEMBL. | 16806916 |
IC50 (functional) | = 58 nM | Antiproliferative activity against EGF-stimulated KB cells | ChEMBL. | 16806916 |
pKa | = 9.3 | Dissociation constant, pKa of the compound | ChEMBL. | 16806916 |
Solubility | = 1885 uM | Aqueous solubility at pH 7.4 | ChEMBL. | 16806916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.