Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0036 | 0.0025 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0137 | 0.0219 | 0.1392 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0036 | 0.002 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0489 | 0.1356 | 0.5018 |
Brugia malayi | Hemopexin family protein | 0.008 | 0.0036 | 0.005 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0489 | 0.1356 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0204 | 0.0438 | 0.3049 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0867 | 0.2571 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0867 | 0.2571 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0867 | 0.2571 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0068 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0125 | 0.0181 | 0.0145 |
Echinococcus multilocularis | high affinity cgmp specific 3' 5' cyclic | 0.0489 | 0.1356 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.2306 | 0.7208 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0148 | 0.0256 | 0.0355 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0148 | 0.0256 | 0.1671 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0867 | 0.2571 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0233 | 0.0531 | 0.3752 |
Loa Loa (eye worm) | matrixin family protein | 0.0136 | 0.0217 | 0.4095 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0137 | 0.0219 | 0.1392 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0109 | 0.0132 | 0.073 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0148 | 0.0256 | 0.4826 |
Schistosoma mansoni | lipoxygenase | 0.0137 | 0.0219 | 0.1409 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0036 | 0.002 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0082 | 0.0044 | 0.0085 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0109 | 0.0132 | 0.073 |
Brugia malayi | Matrixin family protein | 0.0136 | 0.0217 | 0.0302 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.0233 | 0.0531 | 0.0736 |
Loa Loa (eye worm) | matrixin family protein | 0.0125 | 0.0181 | 0.3413 |
Schistosoma mansoni | lipoxygenase | 0.0095 | 0.0087 | 0.0409 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0125 | 0.0181 | 0.0145 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0233 | 0.0531 | 0.3752 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.0256 | 0.1688 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0204 | 0.0438 | 0.3049 |
Echinococcus granulosus | high affinity cgmp specific 3' 5' cyclic | 0.0489 | 0.1356 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0148 | 0.0256 | 0.1671 |
Loa Loa (eye worm) | PDE1B protein | 0.0233 | 0.0531 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0233 | 0.0531 | 0.3765 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0068 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.01 | Potency of compound was determined in rat vas deferens relative to substance E | ChEMBL. | 6182294 |
Potency (functional) | = 0.01 | Potency of compound was determined in hamster bladder relative to substance E | ChEMBL. | 6182294 |
Potency (functional) | = 0.02 | Potency of compound was determined in rat duodenum relative to substance E | ChEMBL. | 6182294 |
Potency (functional) | = 0.52 | Potency of compound was determined for contraction of guinea pig vas deferens relative to substance P(=1) | ChEMBL. | 6182294 |
Potency (functional) | = 0.61 | Potency of compound was determined for contraction of rat bladder relative to substance P(=1) | ChEMBL. | 6182294 |
Potency (functional) | = 0.95 | Potency of compound was determined for contraction of guinea pig ileum relative to substance P(=1) | ChEMBL. | 6182294 |
Potency (binding) | = 0.95 | Potency of the compound for [3H]-SP binding to Tachykinin receptor 1 in rat brain central nervous system (CNS) | ChEMBL. | 6182294 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.