Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1484 | 0.869 | 0.5 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0319 | 0.0693 | 0.0693 |
Schistosoma mansoni | adenosine kinase | 0.1675 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.0693 | 0.0693 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0319 | 0.0693 | 0.0693 |
Loa Loa (eye worm) | hypothetical protein | 0.1675 | 1 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.1675 | 1 | 0.5 |
Leishmania major | adenosine kinase, putative | 0.1675 | 1 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.1675 | 1 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.1675 | 1 | 0.5 |
Echinococcus granulosus | adenosine kinase | 0.1675 | 1 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.1675 | 1 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.1675 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0319 | 0.0693 | 0.0693 |
Toxoplasma gondii | kinase, pfkB family protein | 0.1675 | 1 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.1675 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 % | Angiotensin II-like agonist activity, measured in the in vitro rabbit aorta strip assay | ChEMBL. | 2724307 |
Blood pressure (functional) | = 5 mmHg | In vivo blood pressure increase produced by a 1 ug bolus i.v. | ChEMBL. | 2724307 |
pA2 (functional) | = 7.1 | Antagonist activity pA2, was measured in the in vitro rabbit aorta strip assay | ChEMBL. | 2724307 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.