Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0811 | 0.1596 | 0.1596 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1568 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0811 | 0.1596 | 0.1899 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1568 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0667 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.1424 | 0.8404 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.1037 | 0.4106 | 0.4106 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0667 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.1424 | 0.8404 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1568 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0811 | 0.1596 | 0.1596 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0667 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1568 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.1037 | 0.4106 | 0.4106 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.1173 | 0.5613 | 0.5613 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0667 | 0 | 0.5 |
Echinococcus multilocularis | NMDA receptor | 0.1037 | 0.4106 | 0.4106 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.1037 | 0.4106 | 0.4106 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0811 | 0.1596 | 0.1596 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1568 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0811 | 0.1596 | 0.1596 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 3.9 dose ratio | In vitro antagonistic activity against Substance P on guinea pig ileum at concentration of 10 uM. | ChEMBL. | 2433442 |
Activity (functional) | = 7.2 dose ratio | In vitro antagonistic activity against Substance P on guinea pig ileum at concentration of 10 uM. | ChEMBL. | 2433442 |
Activity (functional) | = 8.1 dose ratio | Antagonistic activity of the compound against Substance P(6-11) receptor in guinea pig ileum at concentration of 5 uM. | ChEMBL. | 2433442 |
Activity (functional) | = 9.9 dose ratio | In vitro antagonistic activity against Substance P(6-11) in guinea pig ileum at concentration of 10 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = -87 % | Antagonistic activity of the compound against Substance P(6-11) receptor in rat spinal cord at concentration of 25 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = -87 % | Antagonistic activity of the compound against Substance P(6-11) receptor in rat spinal cord at concentration of 50 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = -42 % | Antagonistic activity of the compound against Substance P(6-11) receptor in rat spinal cord at concentration of 5 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = -19 % | Antagonistic activity of the compound against Substance P receptor in rat spinal cord at concentration of 50 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = -3 % | Antagonistic activity of the compound against Glutamate receptor in spinal rat cord at concentration of 5 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = 21 % | Antagonistic activity of the compound against Substance P receptor in rat spinal cord at concentration of 25 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = 27 % | Antagonistic activity of the compound against Glutamate receptor in rat spinal cord at concentration of 50 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = 29 % | Antagonistic activity of the compound against Glutamate receptor in spinal rat cord at concentration of 25 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = 32 % | Antagonistic activity of the compound against Substance P receptor in rat spinal cord at concentration of 5 uM. | ChEMBL. | 2433442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.