Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Furin-like cysteine rich region family protein | 0.0148 | 0.0256 | 0.0355 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0148 | 0.0256 | 0.1671 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0867 | 0.2571 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0125 | 0.0181 | 0.0145 |
Brugia malayi | Telomerase reverse transcriptase | 0.2306 | 0.7208 | 1 |
Echinococcus multilocularis | high affinity cgmp specific 3' 5' cyclic | 0.0489 | 0.1356 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0137 | 0.0219 | 0.1392 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0109 | 0.0132 | 0.073 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0148 | 0.0256 | 0.4826 |
Loa Loa (eye worm) | matrixin family protein | 0.0136 | 0.0217 | 0.4095 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0233 | 0.0531 | 0.3752 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0489 | 0.1356 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0204 | 0.0438 | 0.3049 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0036 | 0.0025 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0137 | 0.0219 | 0.1392 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0036 | 0.002 |
Brugia malayi | Hemopexin family protein | 0.008 | 0.0036 | 0.005 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0489 | 0.1356 | 0.5018 |
Mycobacterium ulcerans | hydrolase | 0.0068 | 0 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0867 | 0.2571 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0867 | 0.2571 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0867 | 0.2571 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0204 | 0.0438 | 0.3049 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0233 | 0.0531 | 0.3752 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.0256 | 0.1688 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0068 | 0 | 0.5 |
Loa Loa (eye worm) | PDE1B protein | 0.0233 | 0.0531 | 1 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0233 | 0.0531 | 0.3765 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0068 | 0 | 0.5 |
Echinococcus granulosus | high affinity cgmp specific 3' 5' cyclic | 0.0489 | 0.1356 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0148 | 0.0256 | 0.1671 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0082 | 0.0044 | 0.0085 |
Schistosoma mansoni | lipoxygenase | 0.0137 | 0.0219 | 0.1409 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0036 | 0.002 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0125 | 0.0181 | 0.0145 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0109 | 0.0132 | 0.073 |
Brugia malayi | Matrixin family protein | 0.0136 | 0.0217 | 0.0302 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.0233 | 0.0531 | 0.0736 |
Loa Loa (eye worm) | matrixin family protein | 0.0125 | 0.0181 | 0.3413 |
Schistosoma mansoni | lipoxygenase | 0.0095 | 0.0087 | 0.0409 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | < 2 dose ratio | In vitro antagonistic activity against Substance P on guinea pig ileum at concentration of 10 uM. | ChEMBL. | 2433442 |
Activity (functional) | < 2 dose ratio | In vitro antagonistic activity against Substance P(6-11) in guinea pig ileum at concentration of 10 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = -75 % | Antagonistic activity of the compound against Substance P(6-11) receptor in rat spinal cord at concentration of 100 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = -55 % | Antagonistic activity of the compound against Substance P(6-11) receptor in rat spinal cord at concentration of 50 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = -22 % | Antagonistic activity of the compound against Substance P(6-11) receptor in rat spinal cord at concentration of 5 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = 15 % | Antagonistic activity of the compound against Substance P receptor in rat spinal cord at concentration of 5 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = 27 % | Antagonistic activity of the compound against Substance P receptor in rat spinal cord at concentration of 50 uM. | ChEMBL. | 2433442 |
Change in amplitude response (functional) | = 59 % | Antagonistic activity of the compound against Substance P receptor in rat spinal cord at concentration of 100 uM. | ChEMBL. | 2433442 |
SP (functional) | < 0.0001 % | Evaluated in vitro for percent agonist activity in guinea pig ileum (substance P receptor) | ChEMBL. | 2433442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.