Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0867 | 0.2571 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0867 | 0.2571 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0867 | 0.2571 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0036 | 0.002 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0137 | 0.0219 | 0.1392 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0036 | 0.0025 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0489 | 0.1356 | 0.5018 |
Brugia malayi | Hemopexin family protein | 0.008 | 0.0036 | 0.005 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0204 | 0.0438 | 0.3049 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0489 | 0.1356 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0136 | 0.0217 | 0.4095 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0233 | 0.0531 | 0.3752 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0148 | 0.0256 | 0.4826 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0137 | 0.0219 | 0.1392 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0109 | 0.0132 | 0.073 |
Onchocerca volvulus | Matrilysin homolog | 0.0125 | 0.0181 | 0.0145 |
Brugia malayi | Telomerase reverse transcriptase | 0.2306 | 0.7208 | 1 |
Echinococcus multilocularis | high affinity cgmp specific 3' 5' cyclic | 0.0489 | 0.1356 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0148 | 0.0256 | 0.1671 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0148 | 0.0256 | 0.0355 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0867 | 0.2571 | 1 |
Brugia malayi | Matrixin family protein | 0.0136 | 0.0217 | 0.0302 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0109 | 0.0132 | 0.073 |
Schistosoma mansoni | lipoxygenase | 0.0095 | 0.0087 | 0.0409 |
Loa Loa (eye worm) | matrixin family protein | 0.0125 | 0.0181 | 0.3413 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.0233 | 0.0531 | 0.0736 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0125 | 0.0181 | 0.0145 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0137 | 0.0219 | 0.1409 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0036 | 0.002 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0082 | 0.0044 | 0.0085 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0867 | 0.2571 | 1 |
Echinococcus granulosus | high affinity cgmp specific 3' 5' cyclic | 0.0489 | 0.1356 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0148 | 0.0256 | 0.1671 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0068 | 0 | 0.5 |
Loa Loa (eye worm) | PDE1B protein | 0.0233 | 0.0531 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0233 | 0.0531 | 0.3765 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.0256 | 0.1688 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0233 | 0.0531 | 0.3752 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0204 | 0.0438 | 0.3049 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Alphax10E (functional) | = 1 | Intrinsic activity was measured on the dog carotid artery. | ChEMBL. | 6177855 |
Alphax10E (functional) | = 1 | Intrinsic activity was measured on the rabbit mesenteric vein. | ChEMBL. | 6177855 |
Alphax10E (functional) | = 1 | Intrinsic activity was measured on the guinea pig ileum. | ChEMBL. | 6177855 |
pD2 (functional) | = 6.95 | Apparent affinity was measured on the rabbit mesenteric vein. | ChEMBL. | 6177855 |
pD2 (functional) | = 8.47 | Apparent affinity was measured on the guinea pig ileum. | ChEMBL. | 6177855 |
pD2 (functional) | = 9.19 | Apparent affinity was measured on the dog carotid artery. | ChEMBL. | 6177855 |
RA (functional) | = 15.5 | Relative affinity compared to substance P was measured in the dog carotid artery. | ChEMBL. | 6177855 |
RA (functional) | = 25.1 | Relative affinity compared to substance P was measured in rabbit mesenteric vein. | ChEMBL. | 6177855 |
RA (functional) | = 49 | Relative affinity compared to substance P was measured in guinea pig ileum. | ChEMBL. | 6177855 |
RP (functional) | = 69 | Relative potency compared substance P - change in blood pressure in anesthetized rat. | ChEMBL. | 6177855 |
SP (functional) | = 13.6 % | Evaluated in vitro for percent agonist activity in guinea pig ileum (substance P receptor) | ChEMBL. | 2433442 |
SP (functional) | = 16 % | Evaluated in vitro for percent agonist activity in guinea pig ileum (substance P receptor) | ChEMBL. | 2433442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.