Detailed information for compound 377566

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1221.32 | Formula: C60H76N12O16
  • H donors: 14 H acceptors: 14 LogP: -2.21 Rotable bonds: 34
    Rule of 5 violations (Lipinski): 4
  • SMILES: O=C(/C=C/C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC1CCC2(C34C1Oc1c4c(CC2N(CC3)CC2CC2)ccc1O)O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC1CCC2(C34C1Oc1c4c(CC2N(CC3)CC2CC2)ccc1O)O
  • InChi: 1S/C60H76N12O16/c73-37-7-5-33-19-39-59(85)13-11-35(55-57(59,51(33)53(37)87-55)15-17-71(39)29-31-1-2-31)69-49(83)27-67-47(81)25-65-45(79)23-63-43(77)21-61-41(75)9-10-42(76)62-22-44(78)64-24-46(80)66-26-48(82)68-28-50(84)70-36-12-14-60(86)40-20-34-6-8-38(74)54-52(34)58(60,56(36)88-54)16-18-72(40)30-32-3-4-32/h5-10,31-32,35-36,39-40,55-56,73-74,85-86H,1-4,11-30H2,(H,61,75)(H,62,76)(H,63,77)(H,64,78)(H,65,79)(H,66,80)(H,67,81)(H,68,82)(H,69,83)(H,70,84)/b10-9+
  • InChiKey: SUDDDJRKXARRCJ-MDZDMXLPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis glycine receptor subunit beta 0.0067 0.0157 0.0107
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0104 0.0438 0.1696
Echinococcus granulosus neuropeptide receptor A26 0.0104 0.0438 0.039
Echinococcus multilocularis growth factor receptor bound protein 2 0.0138 0.0702 0.0655
Echinococcus multilocularis allatostatin A receptor 0.0104 0.0438 0.039
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0067 0.0157 0.0107
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0067 0.0157 0.0107
Loa Loa (eye worm) neuropeptide F receptor 0.0104 0.0438 0.1872
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0067 0.0157 0.0669
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0094 0.0364 0.0316
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0104 0.0438 0.039
Onchocerca volvulus 0.0104 0.0438 0.1289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Echinococcus multilocularis fmrfamide receptor 0.0104 0.0438 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0096 0.1478
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0104 0.0438 0.039
Schistosoma mansoni integrin beta subunit 0.0181 0.1027 0.4269
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0067 0.0157 0.0669
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0438 0.1696
Brugia malayi G-protein coupled receptor 0.0104 0.0438 0.1872
Onchocerca volvulus 0.0352 0.2339 1
Echinococcus granulosus glycine receptor subunit beta 0.0067 0.0157 0.0107
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0104 0.0438 0.039
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.0157 0.0669
Echinococcus granulosus glycine receptor subunit alpha 1 0.0067 0.0157 0.0107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.0157 0.0669
Trypanosoma cruzi target of rapamycin kinase 3 0.0094 0.0364 0.0978
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0104 0.0438 0.039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.005 0.0213
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0096 0.1478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Schistosoma mansoni neuropeptide F-like receptor 0.0104 0.0438 0.1696
Onchocerca volvulus 0.0104 0.0438 0.1289
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0104 0.0438 0.039
Echinococcus granulosus orexin receptor type 2 0.0104 0.0438 0.039
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0104 0.0438 0.1696
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0104 0.0438 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0104 0.0438 0.1872
Giardia lamblia GTOR 0.0094 0.0364 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0067 0.0157 0.0107
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis neuropeptide Y receptor 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0094 0.0364 0.0978
Schistosoma mansoni myosin xvIII 0.0104 0.0438 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0438 0.1696
Loa Loa (eye worm) melatonin receptor type 1A 0.0104 0.0438 0.1872
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0104 0.0438 0.1872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0067 0.0157 0.0669
Loa Loa (eye worm) hypothetical protein 0.0352 0.2339 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Brugia malayi Serotonin receptor 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus granulosus tm gpcr rhodopsin 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Schistosoma mansoni nAChR subunit 0.0067 0.0157 0.0467
Schistosoma mansoni amine GPCR 0.0104 0.0438 0.1696
Echinococcus granulosus neuropeptide FF receptor 2 0.0104 0.0438 0.039
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0067 0.0157 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Echinococcus granulosus g-protein coupled receptor 0.0104 0.0438 0.039
Echinococcus granulosus glycine receptor subunit alpha 1 0.0067 0.0157 0.0107
Echinococcus granulosus biogenic amine 5HT receptor 0.0104 0.0438 0.039
Echinococcus granulosus fmrfamide receptor 0.0104 0.0438 0.039
Brugia malayi larval opioid receptor 0.0104 0.0438 0.1872
Brugia malayi hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis dro:myosuppressin receptor 0.0104 0.0438 0.039
Onchocerca volvulus 0.0104 0.0438 0.1289
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0104 0.0438 0.1872
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0094 0.0364 0.0978
Echinococcus granulosus glycine receptor subunit beta 0.0067 0.0157 0.0107
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Echinococcus multilocularis neuropeptide receptor A26 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis neuropeptide FF receptor 2 0.0104 0.0438 0.039
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0067 0.0157 0.0107
Schistosoma mansoni nAChR subunit 0.0067 0.0157 0.0467
Echinococcus multilocularis g protein coupled receptor 0.0104 0.0438 0.039
Echinococcus multilocularis orexin receptor type 2 0.0104 0.0438 0.039
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0104 0.0438 0.1696
Loa Loa (eye worm) G-protein coupled receptor 0.0104 0.0438 0.1872
Brugia malayi hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis g-protein coupled receptor 0.0104 0.0438 0.039
Onchocerca volvulus 0.0104 0.0438 0.1289
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0104 0.0438 0.1872
Schistosoma mansoni opsin-like receptor 0.0104 0.0438 0.1696
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.0157 0.0669
Echinococcus multilocularis integrin beta 2 0.0228 0.1384 0.1341
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0094 0.0364 0.0316
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Schistosoma mansoni biogenic amine receptor 0.0104 0.0438 0.1696
Brugia malayi G protein-coupled receptor 0.0104 0.0438 0.1872
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0438 0.039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis g protein coupled receptor 0.0104 0.0438 0.039
Schistosoma mansoni adenoreceptor 0.0104 0.0438 0.1696
Onchocerca volvulus 0.0104 0.0438 0.1289
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.005 0.0213
Schistosoma mansoni amine GPCR 0.0104 0.0438 0.1696
Brugia malayi putative neuropeptide receptor NPR1 0.0104 0.0438 0.1872
Schistosoma mansoni histamine h1 receptor 0.0104 0.0438 0.1696
Schistosoma mansoni hypothetical protein 0.0104 0.0438 0.1696
Echinococcus granulosus G protein coupled receptor 139 0.0104 0.0438 0.039
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0067 0.0157 0.0669
Echinococcus granulosus neuropeptide s receptor 0.0104 0.0438 0.039
Echinococcus granulosus 7tm_1 domain containing protein 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0411
Echinococcus granulosus growth factor receptor bound protein 2 0.0138 0.0702 0.0655
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0104 0.0438 0.1872
Schistosoma mansoni growth hormone secretagogue receptor 0.0104 0.0438 0.1696
Loa Loa (eye worm) ACC-1 protein 0.0067 0.0157 0.0669
Schistosoma mansoni biogenic amine (5HT) receptor 0.0104 0.0438 0.1696
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0067 0.0157 0.0107
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0059 0.0096 0.1478
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Loa Loa (eye worm) integrin beta-2 0.0307 0.1994 0.8524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0104 0.0438 0.039
Schistosoma mansoni biogenic amine receptor 0.0104 0.0438 0.1696
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0067 0.0157 0.0107
Onchocerca volvulus 0.0104 0.0438 0.1289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0438 0.039
Onchocerca volvulus 0.0104 0.0438 0.1289
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0094 0.0364 1
Schistosoma mansoni nAChR subunit 0.0067 0.0157 0.0467
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0352 0.2339 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0067 0.0157 0.0107
Brugia malayi putative neuropeptide receptor 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0067 0.0157 0.0107
Schistosoma mansoni growth factor receptor-bound protein 0.0138 0.0702 0.2847
Brugia malayi hypothetical protein 0.0104 0.0438 0.1872
Brugia malayi Dopamine receptor 0.0104 0.0438 0.1872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0438 0.1696
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0067 0.0157 0.0669
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0104 0.0438 0.039
Schistosoma mansoni nAChR subunit 0.0067 0.0157 0.0467
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0364 0.1558
Loa Loa (eye worm) TYRA-2 protein 0.0104 0.0438 0.1872
Loa Loa (eye worm) neuropeptide F receptor 0.0104 0.0438 0.1872
Brugia malayi Integrin beta pat-3 precursor 0.0307 0.1994 0.8524
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0438 0.039
Echinococcus granulosus neuropeptide Y receptor 0.0104 0.0438 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0094 0.0364 0.1374
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis neuropeptide Y receptor 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Brugia malayi Serotonin receptor 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0104 0.0438 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0067 0.0157 0.0107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.0157 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0094 0.0364 0.0978
Loa Loa (eye worm) hypothetical protein 0.0312 0.203 0.868
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0438 0.039
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0094 0.0364 1
Brugia malayi GnHR receptor homolog 0.0104 0.0438 0.1872
Echinococcus multilocularis fmrfamide receptor 0.0104 0.0438 0.039
Echinococcus multilocularis sex peptide receptor 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0094 0.0364 1
Leishmania major hypothetical protein, conserved 0.0491 0.3404 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0104 0.0438 0.039
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0104 0.0438 0.039
Echinococcus multilocularis neuropeptide s receptor 0.0104 0.0438 0.039
Schistosoma mansoni nAChR subunit 0.0067 0.0157 0.0467
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus granulosus somatostatin receptor 0.0104 0.0438 0.039
Echinococcus granulosus neuropeptide receptor 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Schistosoma mansoni biogenic amine (5HT) receptor 0.0104 0.0438 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0438 0.039
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0067 0.0157 0.0107
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0067 0.0157 0.0669
Echinococcus multilocularis nAChR subunit 0.0067 0.0157 0.0107
Onchocerca volvulus 0.0352 0.2339 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0104 0.0438 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0104 0.0438 0.1696
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0104 0.0438 0.1696
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0067 0.0157 0.0107
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0364 0.1558
Echinococcus granulosus biogenic amine 5HT receptor 0.0104 0.0438 0.039
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0104 0.0438 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Brugia malayi hypothetical protein 0.0104 0.0438 0.1872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Brugia malayi hypothetical protein 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0053 0.005 0.0213
Echinococcus multilocularis serotonin receptor 0.0104 0.0438 0.039
Schistosoma mansoni nAChR subunit 0.0067 0.0157 0.0467
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0438 0.1696
Schistosoma mansoni neuropeptide receptor 0.0104 0.0438 0.1696
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0094 0.0364 0.0316
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0067 0.0157 0.0669
Echinococcus multilocularis G-protein coupled receptor, putative 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus granulosus neuropeptides capa receptor 0.0104 0.0438 0.039
Echinococcus granulosus g protein coupled receptor 0.0104 0.0438 0.039
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0094 0.0364 1
Schistosoma mansoni amine GPCR 0.0104 0.0438 0.1696
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis glycine receptor subunit beta 0.0067 0.0157 0.0107
Echinococcus multilocularis somatostatin receptor 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0352 0.2339 1
Onchocerca volvulus 0.0104 0.0438 0.1289
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Schistosoma mansoni neuropeptide F-like receptor 0.0104 0.0438 0.1696
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis g protein coupled receptor 0.0104 0.0438 0.039
Brugia malayi Dopamine receptor protein 2 0.0104 0.0438 0.1872
Onchocerca volvulus 0.0104 0.0438 0.1289
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0438 0.039
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0138 0.0702 0.3
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0104 0.0438 0.1696
Echinococcus granulosus nAChR subunit 0.0067 0.0157 0.0107
Loa Loa (eye worm) ACC-1 protein 0.0067 0.0157 0.0669
Loa Loa (eye worm) LGC-31 protein 0.0067 0.0157 0.0669
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0067 0.0157 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0473 0.3265 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0067 0.0157 0.0107
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Schistosoma mansoni opsin-like receptor 0.0104 0.0438 0.1696
Onchocerca volvulus 0.0352 0.2339 1
Onchocerca volvulus 0.0104 0.0438 0.1289
Echinococcus granulosus g protein coupled receptor 0.0104 0.0438 0.039
Brugia malayi hypothetical protein 0.0104 0.0438 0.1872
Echinococcus granulosus neuropeptide receptor 0.0104 0.0438 0.039
Echinococcus granulosus tachykinin peptides receptor 99D 0.0104 0.0438 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0094 0.0364 0.0978
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0438 0.1696
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0104 0.0438 0.039
Brugia malayi Dopamine receptor protein 1 0.0104 0.0438 0.1872
Echinococcus multilocularis G protein coupled receptor 139 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0438 0.1696
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0067 0.0157 0.0669
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0438 0.1696
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Onchocerca volvulus 0.0104 0.0438 0.1289
Brugia malayi Melatonin receptor type 1A 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0438 0.039
Loa Loa (eye worm) G-protein coupled receptor 0.0104 0.0438 0.1872
Echinococcus granulosus allatostatin A receptor 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0104 0.0438 0.039
Onchocerca volvulus 0.0104 0.0438 0.1289
Echinococcus granulosus integrin beta 2 0.0228 0.1384 0.1341
Onchocerca volvulus 0.0104 0.0438 0.1289
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0067 0.0157 0.0669
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0067 0.0157 0.0107
Brugia malayi sulfakinin receptor protein 0.0104 0.0438 0.1872
Brugia malayi excitatory GABA receptor EXP-1A 0.0067 0.0157 0.0669
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0059 0.0096 0.1478
Echinococcus granulosus neuropeptides capa receptor 0.0104 0.0438 0.039
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1353 1 1
Schistosoma mansoni neuropeptide receptor 0.0104 0.0438 0.1696
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0094 0.0364 1
Brugia malayi AKH receptor 0.0104 0.0438 0.1872
Onchocerca volvulus 0.0104 0.0438 0.1289
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0364 0.1558
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0067 0.0157 0.0669
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0067 0.0157 0.0669
Echinococcus granulosus glycine receptor subunit alpha 1 0.0067 0.0157 0.0107
Brugia malayi Sex muscle abnormal protein 5 0.0138 0.0702 0.3
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus granulosus g protein coupled receptor 0.0104 0.0438 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Schistosoma mansoni hypothetical protein 0.0104 0.0438 0.1696
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.0438 0.1696
Brugia malayi G protein-coupled receptor F59B2.13 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Brugia malayi G-protein coupled receptor 0.0104 0.0438 0.1872
Onchocerca volvulus 0.0104 0.0438 0.1289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.0438 0.1696
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0438 0.1696
Echinococcus granulosus alpha 1A adrenergic receptor 0.0104 0.0438 0.039
Schistosoma mansoni amine GPCR 0.0104 0.0438 0.1696
Schistosoma mansoni growth factor receptor-bound protein 0.0138 0.0702 0.2847
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Schistosoma mansoni alpha-1 adrenergic receptor 0.0104 0.0438 0.1696
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0104 0.0438 0.1696
Brugia malayi follicle stimulating hormone receptor 0.0104 0.0438 0.1872
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0067 0.0157 0.0467
Onchocerca volvulus Neuropeptide F receptor homolog 0.0104 0.0438 0.1289
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0067 0.0157 0.0467
Schistosoma mansoni opsin-like receptor 0.0104 0.0438 0.1696
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0067 0.0157 0.0467
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0352 0.2339 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0067 0.0157 0.0669
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Brugia malayi ORL1-like opioid receptor 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0104 0.0438 0.1696
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0438 0.039
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0104 0.0438 0.039
Echinococcus granulosus hypothetical protein 0.0104 0.0438 0.039
Echinococcus granulosus dro:myosuppressin receptor 0.0104 0.0438 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0364 0.1558
Echinococcus granulosus peptide allatostatin:somatostatin 0.0104 0.0438 0.039
Schistosoma mansoni hypothetical protein 0.0104 0.0438 0.1696
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.0157 0.0669
Brugia malayi Cation transporter family protein 0.0352 0.2339 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0104 0.0438 0.039
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0067 0.0157 0.0669
Brugia malayi hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0067 0.0157 0.0107
Echinococcus multilocularis neuropeptide receptor 0.0104 0.0438 0.039
Brugia malayi hypothetical protein 0.0104 0.0438 0.1872
Schistosoma mansoni neuropeptide receptor 0.0104 0.0438 0.1696
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0104 0.0438 0.039
Schistosoma mansoni hypothetical protein 0.0104 0.0438 0.1696
Echinococcus granulosus 7TM GPCR rhodopsin 0.0104 0.0438 0.039
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0094 0.0364 0.1374
Brugia malayi neuropeptide F receptor 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus multilocularis neuropeptide receptor 0.0104 0.0438 0.039
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0094 0.0364 1
Schistosoma mansoni biogenic amine receptor 0.0104 0.0438 0.1696
Echinococcus multilocularis serotonin receptor 0.0104 0.0438 0.039
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Brugia malayi Cation transporter family protein 0.0067 0.0157 0.0669
Loa Loa (eye worm) hypothetical protein 0.0067 0.0157 0.0669
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0104 0.0438 0.1696
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus granulosus sex peptide receptor 0.0104 0.0438 0.039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0438 0.1696
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0067 0.0157 0.0107
Schistosoma mansoni amine GPCR 0.0104 0.0438 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Brugia malayi hypothetical protein 0.0104 0.0438 0.1872
Brugia malayi neuropeptide F receptor 0.0104 0.0438 0.1872
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0104 0.0438 0.039
Echinococcus granulosus serotonin receptor 0.0104 0.0438 0.039
Echinococcus multilocularis neuropeptides capa receptor 0.0104 0.0438 0.039
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0094 0.0364 0.0316
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.0157 0.0669
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0067 0.0157 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0438 0.039
Echinococcus granulosus tm gpcr rhodopsin 0.0104 0.0438 0.039
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0067 0.0157 0.0669
Brugia malayi Cation transporter family protein 0.0067 0.0157 0.0669
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0104 0.0438 0.1872
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0067 0.0157 0.0107
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0067 0.0157 0.0669
Onchocerca volvulus 0.0104 0.0438 0.1289
Schistosoma mansoni neuropeptide receptor 0.0104 0.0438 0.1696
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0094 0.0364 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.0438 0.1696
Brugia malayi RE15519p 0.0104 0.0438 0.1872
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0094 0.0364 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0104 0.0438 0.1872
Schistosoma mansoni neuropeptide f receptor 76f 0.0104 0.0438 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Echinococcus granulosus tm gpcr rhodopsin 0.0104 0.0438 0.039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0438 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Echinococcus multilocularis neuropeptides capa receptor 0.0104 0.0438 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0364 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0067 0.0157 0.0669
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Loa Loa (eye worm) hypothetical protein 0.0104 0.0438 0.1872
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0438 0.039
Brugia malayi hypothetical protein 0.0104 0.0438 0.1872
Onchocerca volvulus 0.0104 0.0438 0.1289
Brugia malayi Tachykinin-like peptides receptor 99D 0.0104 0.0438 0.1872
Schistosoma mansoni nAChR subunit 0.0067 0.0157 0.0467
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0104 0.0438 0.1289
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0104 0.0438 0.1872

Activities

Activity type Activity value Assay description Source Reference
Ratio (functional) = 3.3 Ratio of IC50 of compound in presence of ethylketazocine(EK) on the electrically stimulated guinea pig ileal longitudinal muscle (GPI) to that of IC50 of control value ChEMBL. 3018242
Ratio (functional) = 22.7 Ratio of IC50 of compound in presence of morphine on the electrically stimulated guinea pig ileal longitudinal muscle (GPI) to that of IC50 of control value ChEMBL. 3018242
Relative potency (functional) = 2.2 Compound was tested for for its antagonistic activity with ethylketazocine(EK) activity on the electrically stimulated guinea pig ileal longitudinal muscle (GPI). ChEMBL. 3018242
Relative potency (functional) = 9.9 Compound was tested for its antagonistic activity with morphine on the electrically stimulated guinea pig ileal longitudinal muscle (GPI). ChEMBL. 3018242

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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