TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 993.111 | Formula: C52H64N8O12
H donors: 10 H acceptors: 10 LogP: 0.4 Rotable bonds: 22
Rule of 5 violations (Lipinski): 3
SMILES: O=C(/C=C/C(=O)NCC(=O)NCC(=O)NC1CCC2(C34C1Oc1c4c(CC2N(CC3)CC2CC2)ccc1O)O)NCC(=O)NCC(=O)NC1CCC2(C34C1Oc1c4c(CC2N(CC3)CC2CC2)ccc1O)O
InChi: 1S/C52H64N8O12/c61-33-7-5-29-19-35-51(69)13-11-31(47-49(51,43(29)45(33)71-47)15-17-59(35)25-27-1-2-27)57-41(67)23-55-39(65)21-53-37(63)9-10-38(64)54-22-40(66)56-24-42(68)58-32-12-14-52(70)36-20-30-6-8-34(62)46-44(30)50(52,48(32)72-46)16-18-60(36)26-28-3-4-28/h5-10,27-28,31-32,35-36,47-48,61-62,69-70H,1-4,11-26H2,(H,53,63)(H,54,64)(H,55,65)(H,56,66)(H,57,67)(H,58,68)/b10-9+
InChiKey: CKBDKHWTSYMHNX-MDZDMXLPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus multilocularis	neuropeptide Y receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0094	0.0364	0.1374
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Brugia malayi	Integrin beta pat-3 precursor	0.0307	0.1994	0.8524
Loa Loa (eye worm)	neuropeptide F receptor	0.0104	0.0438	0.1872
Loa Loa (eye worm)	TYRA-2 protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	phosphatidylinositol 3	0.0094	0.0364	0.1558
Echinococcus granulosus	neuropeptide Y receptor	0.0104	0.0438	0.039
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0067	0.0157	0.0669
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.0438	0.1696
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	nAChR subunit	0.0067	0.0157	0.0467
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Brugia malayi	Dopamine receptor	0.0104	0.0438	0.1872
Brugia malayi	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	growth factor receptor-bound protein	0.0138	0.0702	0.2847
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0067	0.0157	0.0107
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0067	0.0157	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Brugia malayi	putative neuropeptide receptor	0.0104	0.0438	0.1872
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0352	0.2339	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0094	0.0364	1
Schistosoma mansoni	nAChR subunit	0.0067	0.0157	0.0467
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0104	0.0438	0.039
Schistosoma mansoni	biogenic amine receptor	0.0104	0.0438	0.1696
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Onchocerca volvulus		0.0104	0.0438	0.1289
Onchocerca volvulus		0.0104	0.0438	0.1289
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0067	0.0157	0.0107
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Loa Loa (eye worm)	integrin beta-2	0.0307	0.1994	0.8524
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0067	0.0157	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0059	0.0096	0.1478
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0104	0.0438	0.1696
Loa Loa (eye worm)	ACC-1 protein	0.0067	0.0157	0.0669
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0104	0.0438	0.1872
Echinococcus granulosus	growth factor receptor bound protein 2	0.0138	0.0702	0.0655
Schistosoma mansoni	growth hormone secretagogue receptor	0.0104	0.0438	0.1696
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0067	0.0157	0.0669
Echinococcus granulosus	7tm_1 domain containing protein	0.0104	0.0438	0.039
Echinococcus granulosus	neuropeptide s receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0096	0.0411
Echinococcus granulosus	G protein coupled receptor 139	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.0157	0.0669
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0094	0.0364	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0053	0.005	0.0213
Brugia malayi	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	neuropeptide receptor	0.0104	0.0438	0.1696
Echinococcus multilocularis	serotonin receptor	0.0104	0.0438	0.039
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.0438	0.1696
Schistosoma mansoni	nAChR subunit	0.0067	0.0157	0.0467
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Brugia malayi	hypothetical protein	0.0104	0.0438	0.1872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0104	0.0438	0.1696
Echinococcus granulosus	biogenic amine 5HT receptor	0.0104	0.0438	0.039
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0094	0.0364	0.1558
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0104	0.0438	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0104	0.0438	0.1696
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0067	0.0157	0.0107
Onchocerca volvulus		0.0352	0.2339	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0104	0.0438	0.039
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0067	0.0157	0.0107
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Echinococcus multilocularis	nAChR subunit	0.0067	0.0157	0.0107
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0067	0.0157	0.0669
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0104	0.0438	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus granulosus	somatostatin receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus granulosus	neuropeptide receptor	0.0104	0.0438	0.039
Schistosoma mansoni	nAChR subunit	0.0067	0.0157	0.0467
Echinococcus multilocularis	neuropeptide s receptor	0.0104	0.0438	0.039
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0094	0.0364	1
Leishmania major	hypothetical protein, conserved	0.0491	0.3404	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0104	0.0438	0.039
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Echinococcus multilocularis	sex peptide receptor	0.0104	0.0438	0.039
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0094	0.0364	1
Brugia malayi	GnHR receptor homolog	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0312	0.203	0.868
Echinococcus multilocularis	fmrfamide receptor	0.0104	0.0438	0.039
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0157	0.0669
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.0157	0.0107
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0094	0.0364	0.0978
Brugia malayi	Serotonin receptor	0.0104	0.0438	0.1872
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0104	0.0438	0.039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Echinococcus granulosus	neuropeptide Y receptor	0.0104	0.0438	0.039
Giardia lamblia	GTOR	0.0094	0.0364	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0067	0.0157	0.0107
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0104	0.0438	0.1872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0104	0.0438	0.1696
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0104	0.0438	0.039
Echinococcus granulosus	orexin receptor type 2	0.0104	0.0438	0.039
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0104	0.0438	0.039
Schistosoma mansoni	neuropeptide F-like receptor	0.0104	0.0438	0.1696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Onchocerca volvulus		0.0104	0.0438	0.1289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0096	0.1478
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0157	0.0669
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.0157	0.0107
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0053	0.005	0.0213
Trypanosoma cruzi	target of rapamycin kinase 3	0.0094	0.0364	0.0978
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0104	0.0438	0.039
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0157	0.0669
Echinococcus granulosus	glycine receptor subunit beta	0.0067	0.0157	0.0107
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0104	0.0438	0.1872
Onchocerca volvulus		0.0352	0.2339	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0067	0.0157	0.0669
Schistosoma mansoni	integrin beta subunit	0.0181	0.1027	0.4269
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.0438	0.1696
Brugia malayi	G-protein coupled receptor	0.0104	0.0438	0.1872
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0096	0.1478
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0104	0.0438	0.039
Onchocerca volvulus		0.0104	0.0438	0.1289
Echinococcus multilocularis	fmrfamide receptor	0.0104	0.0438	0.039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0067	0.0157	0.0669
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0104	0.0438	0.039
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0094	0.0364	0.0316
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	neuropeptide F receptor	0.0104	0.0438	0.1872
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0067	0.0157	0.0107
Echinococcus multilocularis	glycine receptor subunit beta	0.0067	0.0157	0.0107
Echinococcus multilocularis	allatostatin A receptor	0.0104	0.0438	0.039
Echinococcus granulosus	neuropeptide receptor A26	0.0104	0.0438	0.039
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0067	0.0157	0.0107
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0138	0.0702	0.0655
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0104	0.0438	0.1696
Schistosoma mansoni	hypothetical protein	0.0104	0.0438	0.1696
Onchocerca volvulus		0.0104	0.0438	0.1289
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0053	0.005	0.0213
Echinococcus multilocularis	g protein coupled receptor	0.0104	0.0438	0.039
Schistosoma mansoni	adenoreceptor	0.0104	0.0438	0.1696
Schistosoma mansoni	histamine h1 receptor	0.0104	0.0438	0.1696
Schistosoma mansoni	amine GPCR	0.0104	0.0438	0.1696
Brugia malayi	putative neuropeptide receptor NPR1	0.0104	0.0438	0.1872
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0157	0.0669
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0094	0.0364	0.0316
Brugia malayi	G protein-coupled receptor	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	biogenic amine receptor	0.0104	0.0438	0.1696
Echinococcus multilocularis	integrin beta 2	0.0228	0.1384	0.1341
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0104	0.0438	0.1872
Schistosoma mansoni	opsin-like receptor	0.0104	0.0438	0.1696
Loa Loa (eye worm)	G-protein coupled receptor	0.0104	0.0438	0.1872
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0104	0.0438	0.1696
Onchocerca volvulus		0.0104	0.0438	0.1289
Echinococcus multilocularis	g-protein coupled receptor	0.0104	0.0438	0.039
Brugia malayi	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0067	0.0157	0.0107
Echinococcus multilocularis	orexin receptor type 2	0.0104	0.0438	0.039
Echinococcus multilocularis	g protein coupled receptor	0.0104	0.0438	0.039
Schistosoma mansoni	nAChR subunit	0.0067	0.0157	0.0467
Echinococcus granulosus	glycine receptor subunit beta	0.0067	0.0157	0.0107
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0094	0.0364	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Echinococcus multilocularis	neuropeptide receptor A26	0.0104	0.0438	0.039
Brugia malayi	hypothetical protein	0.0104	0.0438	0.1872
Brugia malayi	larval opioid receptor	0.0104	0.0438	0.1872
Echinococcus granulosus	fmrfamide receptor	0.0104	0.0438	0.039
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0104	0.0438	0.1872
Onchocerca volvulus		0.0104	0.0438	0.1289
Echinococcus multilocularis	dro:myosuppressin receptor	0.0104	0.0438	0.039
Echinococcus granulosus	g-protein coupled receptor	0.0104	0.0438	0.039
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.0157	0.0107
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0067	0.0157	0.0467
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0104	0.0438	0.039
Schistosoma mansoni	nAChR subunit	0.0067	0.0157	0.0467
Schistosoma mansoni	amine GPCR	0.0104	0.0438	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus granulosus	neuropeptide FF receptor 2	0.0104	0.0438	0.039
Echinococcus granulosus	tm gpcr rhodopsin	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0067	0.0157	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0352	0.2339	1
Brugia malayi	Serotonin receptor	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.0438	0.1696
Loa Loa (eye worm)	melatonin receptor type 1A	0.0104	0.0438	0.1872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0104	0.0438	0.1872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Schistosoma mansoni	myosin xvIII	0.0104	0.0438	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Echinococcus multilocularis	neuropeptide Y receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0094	0.0364	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus granulosus	sex peptide receptor	0.0104	0.0438	0.039
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.0438	0.1696
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0104	0.0438	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Brugia malayi	Cation transporter family protein	0.0067	0.0157	0.0669
Echinococcus multilocularis	serotonin receptor	0.0104	0.0438	0.039
Schistosoma mansoni	biogenic amine receptor	0.0104	0.0438	0.1696
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0094	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Echinococcus multilocularis	neuropeptide receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0094	0.0364	0.1374
Schistosoma mansoni	hypothetical protein	0.0104	0.0438	0.1696
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0104	0.0438	0.039
Echinococcus granulosus	7TM GPCR rhodopsin	0.0104	0.0438	0.039
Brugia malayi	neuropeptide F receptor	0.0104	0.0438	0.1872
Echinococcus multilocularis	neuropeptide receptor	0.0104	0.0438	0.039
Schistosoma mansoni	neuropeptide receptor	0.0104	0.0438	0.1696
Brugia malayi	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0067	0.0157	0.0669
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.0157	0.0107
Brugia malayi	hypothetical protein	0.0104	0.0438	0.1872
Brugia malayi	Cation transporter family protein	0.0352	0.2339	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0157	0.0669
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	phosphatidylinositol 3	0.0094	0.0364	0.1558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0104	0.0438	0.039
Schistosoma mansoni	hypothetical protein	0.0104	0.0438	0.1696
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0104	0.0438	0.039
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0104	0.0438	0.039
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0104	0.0438	0.1696
Echinococcus granulosus	hypothetical protein	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Brugia malayi	ORL1-like opioid receptor	0.0104	0.0438	0.1872
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0352	0.2339	1
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0067	0.0157	0.0669
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.0157	0.0467
Schistosoma mansoni	opsin-like receptor	0.0104	0.0438	0.1696
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0104	0.0438	0.1289
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.0157	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0104	0.0438	0.1696
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.0157	0.0467
Brugia malayi	follicle stimulating hormone receptor	0.0104	0.0438	0.1872
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0104	0.0438	0.1872
Onchocerca volvulus		0.0104	0.0438	0.1289
Brugia malayi	hypothetical protein	0.0104	0.0438	0.1872
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0104	0.0438	0.1289
Schistosoma mansoni	nAChR subunit	0.0067	0.0157	0.0467
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0104	0.0438	0.1872
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0067	0.0157	0.0669
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0104	0.0438	0.039
Schistosoma mansoni	neuropeptide f receptor 76f	0.0104	0.0438	0.1696
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0104	0.0438	0.1872
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0094	0.0364	1
Schistosoma mansoni	neuropeptide receptor	0.0104	0.0438	0.1696
Brugia malayi	RE15519p	0.0104	0.0438	0.1872
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0104	0.0438	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0094	0.0364	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0067	0.0157	0.0669
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0067	0.0157	0.0107
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0104	0.0438	0.1872
Onchocerca volvulus		0.0104	0.0438	0.1289
Echinococcus granulosus	tm gpcr rhodopsin	0.0104	0.0438	0.039
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.0157	0.0669
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0067	0.0157	0.0107
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0157	0.0669
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Brugia malayi	Cation transporter family protein	0.0067	0.0157	0.0669
Echinococcus multilocularis	neuropeptides capa receptor	0.0104	0.0438	0.039
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0094	0.0364	0.0316
Echinococcus granulosus	serotonin receptor	0.0104	0.0438	0.039
Brugia malayi	neuropeptide F receptor	0.0104	0.0438	0.1872
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0104	0.0438	0.039
Schistosoma mansoni	amine GPCR	0.0104	0.0438	0.1696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Brugia malayi	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0067	0.0157	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.0438	0.1696
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0104	0.0438	0.039
Brugia malayi	Dopamine receptor protein 1	0.0104	0.0438	0.1872
Echinococcus multilocularis	G protein coupled receptor 139	0.0104	0.0438	0.039
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.0438	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0094	0.0364	0.0978
Echinococcus granulosus	neuropeptide receptor	0.0104	0.0438	0.039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0104	0.0438	0.039
Onchocerca volvulus		0.0104	0.0438	0.1289
Echinococcus granulosus	g protein coupled receptor	0.0104	0.0438	0.039
Brugia malayi	hypothetical protein	0.0104	0.0438	0.1872
Onchocerca volvulus		0.0352	0.2339	1
Schistosoma mansoni	opsin-like receptor	0.0104	0.0438	0.1696
Trypanosoma cruzi	hypothetical protein, conserved	0.0473	0.3265	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.0157	0.0107
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0067	0.0157	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0104	0.0438	0.039
Loa Loa (eye worm)	ACC-1 protein	0.0067	0.0157	0.0669
Loa Loa (eye worm)	LGC-31 protein	0.0067	0.0157	0.0669
Echinococcus granulosus	nAChR subunit	0.0067	0.0157	0.0107
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0104	0.0438	0.1696
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0138	0.0702	0.3
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0669
Brugia malayi	Dopamine receptor protein 2	0.0104	0.0438	0.1872
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Onchocerca volvulus		0.0104	0.0438	0.1289
Schistosoma mansoni	neuropeptide F-like receptor	0.0104	0.0438	0.1696
Echinococcus multilocularis	g protein coupled receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus multilocularis	glycine receptor subunit beta	0.0067	0.0157	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0352	0.2339	1
Onchocerca volvulus		0.0104	0.0438	0.1289
Echinococcus multilocularis	somatostatin receptor	0.0104	0.0438	0.039
Echinococcus granulosus	neuropeptides capa receptor	0.0104	0.0438	0.039
Echinococcus granulosus	g protein coupled receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	amine GPCR	0.0104	0.0438	0.1696
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0094	0.0364	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0104	0.0438	0.1696
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0104	0.0438	0.039
Schistosoma mansoni	growth factor receptor-bound protein	0.0138	0.0702	0.2847
Schistosoma mansoni	amine GPCR	0.0104	0.0438	0.1696
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0104	0.0438	0.1696
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.0438	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Brugia malayi	G-protein coupled receptor	0.0104	0.0438	0.1872
Onchocerca volvulus		0.0104	0.0438	0.1289
Schistosoma mansoni	hypothetical protein	0.0104	0.0438	0.1696
Brugia malayi	G protein-coupled receptor F59B2.13	0.0104	0.0438	0.1872
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0104	0.0438	0.1696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus granulosus	g protein coupled receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0067	0.0157	0.0669
Brugia malayi	Sex muscle abnormal protein 5	0.0138	0.0702	0.3
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.0157	0.0107
Onchocerca volvulus		0.0104	0.0438	0.1289
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0067	0.0157	0.0669
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0094	0.0364	0.1558
Echinococcus granulosus	neuropeptides capa receptor	0.0104	0.0438	0.039
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0059	0.0096	0.1478
Brugia malayi	AKH receptor	0.0104	0.0438	0.1872
Schistosoma mansoni	neuropeptide receptor	0.0104	0.0438	0.1696
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.1353	1	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0094	0.0364	1
Brugia malayi	sulfakinin receptor protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Brugia malayi	excitatory GABA receptor EXP-1A	0.0067	0.0157	0.0669
Onchocerca volvulus		0.0104	0.0438	0.1289
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0067	0.0157	0.0107
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.0157	0.0669
Echinococcus granulosus	integrin beta 2	0.0228	0.1384	0.1341
Onchocerca volvulus		0.0104	0.0438	0.1289
Echinococcus granulosus	allatostatin A receptor	0.0104	0.0438	0.039
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Loa Loa (eye worm)	G-protein coupled receptor	0.0104	0.0438	0.1872
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.0438	0.039
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Brugia malayi	Melatonin receptor type 1A	0.0104	0.0438	0.1872
Onchocerca volvulus		0.0104	0.0438	0.1289
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0067	0.0157	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0438	0.1872
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.0438	0.1696

Activities

Activity type	Activity value	Assay description	Source	Reference
Ratio (functional)	= 19.6	Ratio of IC50 of compound in presence of ethylketazocine(EK) on the electrically stimulated guinea pig ileal longitudinal muscle (GPI) to that of IC50 of control value	ChEMBL.	3018242
Ratio (functional)	= 100	Ratio of IC50 of compound in presence of morphine on the electrically stimulated guinea pig ileal longitudinal muscle (GPI) to that of IC50 of control value	ChEMBL.	3018242
Relative potency (functional)	= 13.1	Compound was tested for for its antagonistic activity with ethylketazocine(EK) activity on the electrically stimulated guinea pig ileal longitudinal muscle (GPI).	ChEMBL.	3018242
Relative potency (functional)	= 43	Compound was tested for its antagonistic activity with morphine on the electrically stimulated guinea pig ileal longitudinal muscle (GPI).	ChEMBL.	3018242

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL274612

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 377712