Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.0355 | 0.8069 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0311 | 0.6645 | 0.6645 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0415 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0326 | 0.7127 | 0.1439 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0326 | 0.7127 | 0.7127 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 4.9 uM | In vitro reversal activity versus ~90% block by rocuronium in isolated mouse hemidiaphragm,expressed as effective conc. | ChEMBL. | 11960492 |
ED50 (functional) | = 4.1 uM kg-1 | In vivo reversal activity versus ~90% block by rocuronium in guinea pig | ChEMBL. | 11960492 |
Max reversal (functional) | = 79.3 % | In vivo reversal activity versus ~90% block by rocuronium in guinea pig, expressed as % of maximum reversal at 25.6 umol/kg conc. | ChEMBL. | 11960492 |
Max reversal (functional) | = 93.2 % | In vitro reversal activity versus ~90% block by rocuronium in isolated mouse hemidiaphragm,expressed as % of maximum reversal at 14.4 uM conc. | ChEMBL. | 11960492 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.