Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0179 | 0.0618 | 0.2579 |
Leishmania major | DNA topoisomerase III, putative | 0.0179 | 0.0618 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0202 | 0.0842 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.043 | 0.1653 | 0.2633 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0105 | 0.031 | 0.0362 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0609 | 0.2395 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0609 | 0.2395 | 1 |
Leishmania major | DNA topoisomerase III, putative | 0.0179 | 0.0618 | 0.0755 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0179 | 0.0618 | 0.0755 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1389 | 0.5621 | 1 |
Plasmodium falciparum | DNA topoisomerase 3, putative | 0.0179 | 0.0618 | 0.0425 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0179 | 0.0618 | 0.2579 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0079 | 0.0202 | 0.0842 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.043 | 0.1653 | 0.2633 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0179 | 0.0618 | 0.1897 |
Echinococcus granulosus | heat shock protein | 0.0079 | 0.0202 | 0.0842 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0079 | 0.0202 | 0.0842 |
Wolbachia endosymbiont of Brugia malayi | topoisomerase IA, TopA | 0.0179 | 0.0618 | 0.0425 |
Brugia malayi | Endoplasmin precursor | 0.0079 | 0.0202 | 0.0842 |
Leishmania major | DNA topoisomerase ii | 0.043 | 0.1653 | 0.2633 |
Brugia malayi | Protein kinase domain containing protein | 0.0251 | 0.0915 | 0.382 |
Toxoplasma gondii | DNA topoisomerase family protein | 0.0179 | 0.0618 | 0.0768 |
Leishmania major | DNA topoisomerase 1A | 0.0179 | 0.0618 | 0.0755 |
Schistosoma mansoni | thyroid hormone receptor | 0.0216 | 0.0772 | 0.3221 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0179 | 0.0618 | 0.0755 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0179 | 0.0618 | 0.2579 |
Brugia malayi | heat shock protein 90 | 0.0079 | 0.0202 | 0.0842 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0609 | 0.2395 | 0.2239 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.022 | 0.0786 | 0.0597 |
Echinococcus granulosus | heat shock protein 90 | 0.0079 | 0.0202 | 0.0842 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.022 | 0.0786 | 0.0597 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0609 | 0.2395 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1412 | 0.5716 | 1 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0179 | 0.0618 | 0.1897 |
Schistosoma mansoni | heat shock protein | 0.0079 | 0.0202 | 0.0842 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0369 | 0.1403 | 0.5857 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.2447 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0187 | 0.0648 | 0.2704 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0609 | 0.2395 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0609 | 0.2395 | 1 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0179 | 0.0618 | 0.139 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0609 | 0.2395 | 1 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0253 | 0.0922 | 0.3849 |
Giardia lamblia | DNA topoisomerase III | 0.0179 | 0.0618 | 0.2228 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0179 | 0.0618 | 0.0755 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.022 | 0.0786 | 0.0597 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0369 | 0.1403 | 0.5857 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0179 | 0.0618 | 0.0755 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.2447 | 1 | 1 |
Brugia malayi | kinase, mitochondrial precursor | 0.0079 | 0.0202 | 0.0842 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0179 | 0.0618 | 0.2579 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0803 | 0.3197 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0179 | 0.0618 | 0.2579 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.1396 | 0.5828 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0187 | 0.0648 | 0.2704 |
Onchocerca volvulus | 0.0179 | 0.0618 | 0.2579 | |
Mycobacterium ulcerans | DNA topoisomerase I | 0.0179 | 0.0618 | 0.0425 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1645 | 0.6679 | 0.6611 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0609 | 0.2395 | 1 |
Schistosoma mansoni | endoplasmin | 0.0079 | 0.0202 | 0.0842 |
Echinococcus multilocularis | heat shock protein | 0.0079 | 0.0202 | 0.0842 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0609 | 0.2395 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.022 | 0.0786 | 0.1079 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.022 | 0.0786 | 0.0597 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0179 | 0.0618 | 0.2579 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0079 | 0.0202 | 0.0842 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0179 | 0.0618 | 0.0755 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.043 | 0.1653 | 0.2633 |
Plasmodium falciparum | DNA gyrase subunit A | 0.022 | 0.0786 | 0.0597 |
Schistosoma mansoni | thyroid hormone receptor | 0.0216 | 0.0772 | 0.3221 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0179 | 0.0618 | 0.0425 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0369 | 0.1403 | 0.5857 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0609 | 0.2395 | 0.2239 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0179 | 0.0618 | 0.0755 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0179 | 0.0618 | 0.2579 |
Brugia malayi | GRF zinc finger family protein | 0.0179 | 0.0618 | 0.2579 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.022 | 0.0786 | 0.0597 |
Schistosoma mansoni | DNA topoisomerase II | 0.0609 | 0.2395 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1412 | 0.5716 | 1 |
Treponema pallidum | DNA topoisomerase I (topA) | 0.0179 | 0.0618 | 0.0425 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0079 | 0.0202 | 0.0842 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0609 | 0.2395 | 0.4047 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0179 | 0.0618 | 0.0755 |
Plasmodium vivax | DNA topoisomerase 3, putative | 0.0179 | 0.0618 | 0.0425 |
Trypanosoma brucei | DNA topoisomerase IA, putative | 0.0179 | 0.0618 | 0.0755 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.2447 | 1 | 1 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0251 | 0.0915 | 0.382 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.1559 | 0.6509 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0383 | 0.1461 | 0.6101 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0179 | 0.0618 | 0.1897 |
Echinococcus multilocularis | heat shock protein 90 | 0.0079 | 0.0202 | 0.0842 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0179 | 0.0618 | 0.0768 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.043 | 0.1653 | 0.2633 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.0648 | 0.2704 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0179 | 0.0618 | 0.2579 |
Schistosoma mansoni | endoplasmin | 0.0079 | 0.0202 | 0.0842 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0251 | 0.0915 | 0.382 |
Brugia malayi | DNA topoisomerase III | 0.0179 | 0.0618 | 0.2579 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0179 | 0.0618 | 0.2579 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0609 | 0.2395 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.1559 | 0.6509 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.2447 | 1 | 1 |
Giardia lamblia | DNA topoisomerase III | 0.0179 | 0.0618 | 0.2228 |
Plasmodium falciparum | DNA gyrase subunit B | 0.2447 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.2447 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1412 | 0.5716 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0216 | 0.0772 | 0.3221 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0179 | 0.0618 | 0.1897 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1412 | 0.5716 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0609 | 0.2395 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0079 | 0.0202 | 0.0842 |
Loa Loa (eye worm) | endoplasmin | 0.0079 | 0.0202 | 0.0842 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.022 | 0.0786 | 0.0597 |
Giardia lamblia | DNA topoisomerase II | 0.053 | 0.207 | 1 |
Schistosoma mansoni | heat shock protein | 0.0079 | 0.0202 | 0.0842 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0609 | 0.2395 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.7 nM | Mobilization of intracellular calcium in CHO cells transiently transfected with human Urotensin 2 receptor | ChEMBL. | 11960491 |
Emax (functional) | = 101 % | Compound was evaluated for percent of the maximum response induced by native human Urotensin 2 receptor | ChEMBL. | 11960491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.