Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.159 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.159 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.159 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.159 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.159 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.159 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.159 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.159 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.159 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.159 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.159 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.159 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Ability to displace [3H]-CPP from NMDA receptor in rat brain membrane | ChEMBL. | 1533422 |
IC50 (binding) | > 100 uM | Ability to displace [3H]-CPP from NMDA receptor in rat brain membrane | ChEMBL. | 1533422 |
Inhibition (binding) | = 21 % | Inhibitory activity of the compound evaluated by its ability to displace [3H]-CPP from NMDA receptor in rat cortical membranes at 10E-4 concentration of the compound | ChEMBL. | 1533423 |
Inhibition (binding) | = 21 % | Inhibitory activity of the compound evaluated by its ability to displace [3H]-CPP from NMDA receptor in rat cortical membranes at 10E-4 concentration of the compound | ChEMBL. | 1533423 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.