Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.3717 | 0.4681 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3717 | 0.3717 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.9699 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0081 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0064 | 0.7639 | 0.7639 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0081 | 1 | 1 |
Onchocerca volvulus | 0.0064 | 0.7639 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.7941 | 1 |
Schistosoma mansoni | jun-related protein | 0.0066 | 0.7941 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.3717 | 0.3717 |
Echinococcus multilocularis | jun protein | 0.0081 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3717 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3717 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3717 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3717 | 0.4681 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3717 | 0.5 |
Echinococcus granulosus | jun protein | 0.0081 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.3717 | 0.3717 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19 uM | Inhibition of c-AMP dependent kinase (PKA) catalytic subunit | ChEMBL. | 8289196 |
IC50 (binding) | = 50 uM | Inhibitory activity against protein kinase C of rat brain | ChEMBL. | 8289196 |
IC50 (binding) | = 50 uM | Inhibitory activity against protein kinase C of rat brain | ChEMBL. | 8289196 |
IC50 (binding) | = 75 uM | Inhibitory activity against protein kinase C of rat brain | ChEMBL. | 8289196 |
IC50 (binding) | = 75 uM | Inhibitory activity against protein kinase C of rat brain | ChEMBL. | 8289196 |
IC50 (binding) | = 96 uM | Inhibitory activity against protein kinase C of rat brain | ChEMBL. | 8289196 |
IC50 (binding) | = 96 uM | Inhibitory activity against protein kinase C of rat brain | ChEMBL. | 8289196 |
IC50 (binding) | > 272 uM | Displacement of [3H]-PDBU from protein kinase C | ChEMBL. | 8289196 |
IC50 (binding) | > 272 uM | Displacement of [3H]-PDBU from protein kinase C | ChEMBL. | 8289196 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.